Human DNAJC19 ELISA Kit (V2LY-0626-LY4894)

Name: Human DNAJC19 ELISA Kit
SKU: V2LY-0626-LY4894
Rating: 5 (1 reviews)

See all DNAJC19 antibodies

Compare Online Inquiry

Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.009 ng/mL

Detection Range

0.02-3.5 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

12.5 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

DnaJ (Hsp40) homolog, subfamily C, member 19

Function

Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity).

May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).

Biological Process

Genitalia development Source: UniProtKB
Protein folding Source: UniProtKB
Protein import into mitochondrial matrix Source: GO_Central
Protein targeting to mitochondrion Source: UniProtKB
Regulation of cardiolipin metabolic process Source: UniProtKB
Visual perception Source: UniProtKB

Cellular Location

Mitochondrion inner membrane

Involvement in disease

3-methylglutaconic aciduria 5 (MGCA5):
An autosomal recessive disorder characterized by early-onset dilated cardiomyopathy, growth failure, cerebellar ataxia causing significant motor delays, testicular dysgenesis, growth failure and significant increases in urine organic acids, particularly 3-methylglutaconic acid and 3-methylglutaric acid.

Topology

Mitochondrial intermembrane: 2-3
Helical: 4-24
Mitochondrial matrix: 25-116

Zhou, J., Peng, Y., Gao, Y. C., Chen, T. Y., Li, P. C., Xu, K., ... & Ren, T. (2021). Targeting DNAJC19 overcomes tumor growth and lung metastasis in NSCLC by regulating PI3K/AKT signaling. Cancer Cell International, 21(1), 1-11.

Ren, T. (2021). Targeting DNAJC19 overcomes tumor growth and metastasis in NSCLC by regulating AKT1 signaling.

Janz, A., Chen, R., Regensburger, M., Ueda, Y., Rost, S., Klopocki, E., ... & Gerull, B. (2020). Generation of two patient-derived iPSC lines from siblings (LIBUCi001-A and LIBUCi002-A) and a genetically modified iPSC line (JMUi001-A-1) to mimic dilated cardiomyopathy with ataxia (DCMA) caused by a homozygous DNAJC19 mutation. Stem cell research, 46, 101856.

Lopez, M. R., Hamdan, F., Rezazadeh, A., Aznarez, I., Minassian, B., Cossette, P., ... & Andrade, D. (2019). Seizures, dystonia and progressive cerebellar degeneration in homozygous DNAJC19 mutation without dilated cardiomyopathy or 3-methylglutaconic aciduria (P2. 5-013).

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human DNAJC19 ELISA Kit?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-DNAJC19 Recombinant Antibody (3H4) (CAT#: CBMAB-D1311-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry