Human FNBP1 ELISA Kit (V2LY-0626-LY3677)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.0096 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
71.3 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Formin Binding Protein 1
Function
May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity).

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
Biological Process
Endocytosis Source: UniProtKB-KW
Signal transduction Source: InterPro
Cellular Location
Cytoskeleton; Lysosome; Cytoplasm; Cell membrane; Cell cortex; Cytoplasmic vesicle; Clathrin-coated pit. Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
Involvement in disease
A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with KMT2A/MLL1. The relatively low incidence of the KMT2A/MLL1-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation.

Wang, Z., Tian, Z., Song, X., & Zhang, J. (2022). Membrane tension sensing molecule-FNBP1 is a prognostic biomarker related to immune infiltration in BRCA, LUAD and STAD. BMC immunology, 23(1), 1-15.

Cao, R., Shao, J., Zhang, W., Lin, Y., Huang, Z., & Li, Z. (2021). Silencing long intergenic non-protein coding RNA 00987 inhibits proliferation, migration, and invasion of osteosarcoma cells by sponging miR-376a-5p to regulate FNBP1 expression. Discover Oncology, 12, 1-11.

Yoon, B. K., Hwang, N., Chun, K. H., Lee, Y., Duarte, T. P. M., Kim, J. W., ... & Kim, J. W. (2021). Sp1-induced FNBP1 drives rigorous 3D cell motility in EMT-type gastric cancer cells. International Journal of Molecular Sciences, 22(13), 6784.

Kervarrec, T., Jacques, B. J., Pissaloux, D., Tirode, F., & de la Fouchardière, A. (2021). FNBP1-BRAF fusion in a primary melanoma of the lung. Pathology, 53(6), 785-788.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-FNBP1 Recombinant Antibody (CBXF-0798) (CAT#: V2LY-0925-LY2525)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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