Human GUSB ELISA Kit (V2LY-0626-LY1116)

Go to compare Compare Online Inquiry
Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.22 ng/mL
Detection Range
0.5-60 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
74.7 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
glucuronidase, beta
Function
Plays an important role in the degradation of dermatan and keratan sulfates.
Biological Process
Carbohydrate metabolic process Source: ProtInc
Glucuronoside catabolic process Source: GO_Central
Glycosaminoglycan catabolic process Source: ProtInc
Cellular Location
Lysosome
Involvement in disease
Mucopolysaccharidosis 7 (MPS7):
An autosomal recessive lysosomal storage disease characterized by inability to degrade glucuronic acid-containing glycosaminoglycans. The phenotype is highly variable, ranging from severe lethal hydrops fetalis to mild forms with survival into adulthood. Most patients with the intermediate phenotype show hepatomegaly, skeletal anomalies, coarse facies, and variable degrees of mental impairment.
PTM
N-linked glycosylated with 3 to 4 oligosaccharide chains.

Lieu, L. (2023). Characterization of β-glucuronidase for Enzyme Replacement Therapy in DYT6 Dystonia.

Wei, Y., Tan, H., Yang, R., Yang, F., Liu, D., Huang, B., ... & Liang, Y. (2023). Gut dysbiosis-derived β-glucuronidase promotes the development of endometriosis. Fertility and Sterility.

Müller, A., Aboutara, N., Jungen, H., Szewczyk, A., Piesch, M., & Iwersen-Bergmann, S. (2022). Formation of ethyl glucuronide by beta-glucuronidase. Toxicologie Analytique et Clinique, 34(3), S71-S72.

Xu, D., & Cui, G. (2022). Glucuronidase beta is an early predictive marker for the use of antidepressant in the treatment of glioma patients. Tropical Journal of Pharmaceutical Research, 21(10), 2261-2268.

Kong, X., Zheng, Z., Song, G., Zhang, Z., Liu, H., Kang, J., ... & Xia, Y. (2022). Over-expression of GUSB leads to primary resistance of Anti-PD1 therapy in hepatocellular carcinoma. Frontiers in Immunology, 13, 876048.

Albert, E., Ferrer, B., Torres, I., Serrano, A., Alcaraz, M. J., Buesa, J., ... & Navarro, D. (2021). Amplification of human β‐glucuronidase gene for appraising the accuracy of negative SARS‐CoV‐2 RT‐PCR results in upper respiratory tract specimens. Journal of Medical Virology, 93(1), 48.

Kunihiro, A. G., Luis, P. B., Brickey, J. A., Frye, J. B., Chow, H. H. S., Schneider, C., & Funk, J. L. (2019). Beta-glucuronidase catalyzes deconjugation and activation of curcumin-glucuronide in bone. Journal of natural products, 82(3), 500-509.

Dubot, P., Sabourdy, F., Plat, G., Jubert, C., Cancès, C., Broué, P., ... & Levade, T. (2019). First report of a patient with MPS type VII, due to novel mutations in GUSB, who underwent enzyme replacement and then hematopoietic stem cell transplantation. International Journal of Molecular Sciences, 20(21), 5345.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Human GUSB ELISA Kit?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.