Human HERPUD1 ELISA Kit (V2LY-0626-LY4699)

Name: Human HERPUD1 ELISA Kit
SKU: V2LY-0626-LY4699
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0052 ng/mL

Detection Range

0.01-2 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

43.7 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Homocysteine Inducible ER Protein With Ubiquitin Like Domain 1

Function

Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16289116, PubMed:28827405).

Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982).

Biological Process

Endoplasmic reticulum calcium ion homeostasis Source: ParkinsonsUK-UCL
Endoplasmic reticulum unfolded protein response Source: GO_Central
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
Negative regulation of intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of ER-associated ubiquitin-dependent protein catabolic process Source: ParkinsonsUK-UCL
Protein targeting to ER Source: Ensembl
Regulation of ER-associated ubiquitin-dependent protein catabolic process Source: GO_Central
Regulation of protein ubiquitination Source: Ensembl
Response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
Response to unfolded protein Source: UniProtKB
Retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
Ubiquitin-dependent ERAD pathway Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: GO_Central

Cellular Location

Endoplasmic reticulum membrane

Topology

Cytoplasmic: 1-263
Helical: 264-284
Lumenal: 285-289
Helical: 290-310
Cytoplasmic: 311-391

Xie, W., Shan, Y., Wu, Z., Liu, N., Yang, J., Zhang, H., ... & Guo, H. (2023). Herpud1 deficiency alleviates homocysteine-induced aortic valve calcification. Cell Biology and Toxicology, 1-20.

Alagappan, L. P., Ramaswamy, Y., Sundaramoorthy, D. K., Bhaskar, J., Sarangapani, S., Sen, P., ... & Mathavan, S. (2023). Association of HERPUD1 genetic variant rs2217332 with age-related macular degeneration and polypoidal choroidal vasculopathy in an Indian cohort. Graefe's Archive for Clinical and Experimental Ophthalmology, 261(4), 1205-1212.

Peng, Y., Li, N., Tang, F., Qian, C., Jia, T., Liu, J., & Xu, Y. (2022). Corosolic acid sensitizes ferroptosis by upregulating HERPUD1 in liver cancer cells. Cell Death Discovery, 8(1), 376.

Nie, X., Liu, D., Zheng, M., Li, X., Liu, O., Guo, Q., ... & Lin, B. (2022). HERPUD1 promotes ovarian cancer cell survival by sustaining autophagy and inhibit apoptosis via PI3K/AKT/mTOR and p38 MAPK signaling pathways. BMC cancer, 22(1), 1338.

Mikawa, M., Sakai, C., Yamamoto, T., Nakamura, Y., Tanaka, S., Tominaga, N., ... & Yano, M. (2022). Herpud1 suppress angiotensin II induced hypertrophy in cardiomyocytes. Biochemistry and Biophysics Reports, 30, 101248.

Li, W., Wang, Y., Zhu, L., Du, S., Mao, J., Wang, Y., ... & Yi, Q. (2021). The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization. Journal of Cellular and Molecular Medicine, 25(14), 6709-6720.

Liu, C., Xu, X., Huang, C., Zhang, L., Shang, D., Cai, W., & Wang, Y. (2020). Circ_002664/miR-182–5p/Herpud1 pathway importantly contributes to OGD/R-induced neuronal cell apoptosis. Molecular and cellular probes, 53, 101585.

Li, Y., Xie, Y., Hao, J., Liu, J., Ning, Y., Tang, Q., ... & Lv, X. (2018). ER-localized protein-Herpud1 is a new mediator of IL-4-induced macrophage polarization and migration. Experimental Cell Research, 368(2), 167-173.

Navarro-Marquez, M., Torrealba, N., Troncoso, R., Vásquez-Trincado, C., Rodriguez, M., Morales, P. E., ... & Lavandero, S. (2018). Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(5), 1653-1662.

Américo-Da-Silva, L., Diaz, J., Bustamante, M., Mancilla, G., Oyarzun, I., Verdejo, H. E., & Quiroga, C. (2018). A new role for HERPUD1 and ERAD activation in osteoblast differentiation and mineralization. The FASEB Journal, 32(9), 4681-4695.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

HERPUD1 Matched Antibody Pair (537) (CAT#: APMAB-537LY)

HERPUD1 Matched Antibody Pair (538) (CAT#: APMAB-538LY)

Antibody Pairs

HERPUD1 Matched Antibody Pair (537) (CAT#: APMAB-537LY)

HERPUD1 Matched Antibody Pair (538) (CAT#: APMAB-538LY)

Related Products

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Mouse Anti-HERPUD1 (AA 1-391) Recombinant Antibody (CBFYH-0936) (CAT#: CBMAB-H1869-FY)

Mouse Anti-HERPUD1 Recombinant Antibody (3E10) (CAT#: CBMAB-A3827-LY)

Mouse Anti-HERPUD1 (AA 1-392) Recombinant Antibody (CBFYH-0938) (CAT#: CBMAB-H1871-FY)

HERPUD1 Matched Antibody Pair (537) (CAT#: APMAB-537LY)

Mouse Anti-HERPUD1 (AA 74-180) Recombinant Antibody (CBFYH-0937) (CAT#: CBMAB-H1870-FY)

HERPUD1 Matched Antibody Pair (538) (CAT#: APMAB-538LY)

Isotype control

For research use only. Not intended for any clinical use.

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