Human LAMA1 ELISA Kit (V2LY-0626-LY5887)

Name: Human LAMA1 ELISA Kit
SKU: V2LY-0626-LY5887
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.025 ng/mL

Detection Range

0.05-20 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

337.1 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

laminin, alpha 1

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Biological Process

Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Blood vessel morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Branching involved in salivary gland morphogenesisIEA:Ensembl
Camera-type eye developmentManual Assertion Based On ExperimentIBA:GO_Central
Cell adhesionIEA:UniProtKB-KW
Cell surface receptor signaling pathwayISS:UniProtKB
Epithelial tube branching involved in lung morphogenesisIEA:Ensembl
Establishment of epithelial cell apical/basal polarityIEA:Ensembl
Morphogenesis of an epithelial sheetIEA:Ensembl
Protein phosphorylationIEA:Ensembl
Regulation of cell adhesionIEA:InterPro
Regulation of cell migrationIEA:InterPro
Regulation of embryonic developmentIEA:InterPro
Retinal blood vessel morphogenesisIEA:Ensembl
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted, extracellular space, extracellular matrix, basement membrane
Major component.

Involvement in disease

Poretti-Boltshauser syndrome (PTBHS):
An autosomal recessive disorder characterized by cerebellar dysplasia, cerebellar vermis atrophy, cerebellar cysts in most patients, high myopia, variable retinal dystrophy, and eye movement abnormalities including strabismus, ocular apraxia, nystagmus. Affected individuals have ataxia, delayed motor development, language impairment, and intellectual disability with variable severity.

PTM

Tyrosine phosphorylated by PKDCC/VLK.

Wang, P., Jia, X., Xiao, X., Li, S., Long, Y., Liu, M., ... & Zhang, Q. (2021). An early diagnostic clue for COL18A1-and LAMA1-associated diseases: high myopia with alopecia areata in the cranial midline. Frontiers in Cell and Developmental Biology, 9, 644947.

Powell, L., Olinger, E., Wedderburn, S., Ramakumaran, V. S., Kini, U., Clayton-Smith, J., ... & Sayer, J. A. (2021). Identification of LAMA1 mutations ends diagnostic odyssey and has prognostic implications for patients with presumed Joubert syndrome. Brain Communications, 3(3), fcab163.

Zhou, P. L., Wu, Z., Zhang, W., Xu, M., Ren, J., Zhang, Q., ... & Han, X. (2021). Circular RNA hsa_circ_0000277 sequesters miR-4766-5p to upregulate LAMA1 and promote esophageal carcinoma progression. Cell death & disease, 12(7), 676.

Kurek, M., Åkesson, E., Yoshihara, M., Oliver, E., Cui, Y., Becker, M., ... & Stukenborg, J. B. (2021). Spermatogonia loss correlates with LAMA 1 expression in human prepubertal testes stored for fertility preservation. Cells, 10(2), 241.

Chen, M., Zhang, M., Qian, Y., Yang, Y., Sun, Y., Liu, B., ... & Dong, M. (2020). Identification of a likely pathogenic structural variation in the LAMA1 gene by Bionano optical mapping. NPJ genomic medicine, 5(1), 31.

Elmas, M., Gogus, B., & Solak, M. (2020). Understanding what you have found: a family with a mutation in the LAMA1 gene with literature review. Clinical Medicine Insights: Case Reports, 13, 1179547620948666.

Biler, E. D., Ilim, O., Palamar, M., Onay, H., & Uretmen, O. (2018). TGFB1 and LAMA1 gene polymorphisms in children with high myopia. Pakistan journal of medical sciences, 34(2), 463.

Marlow, E., Chan, R. P., Oltra, E., Rusu, I., & Gupta, M. P. (2018). Retinal avascularity and neovascularization associated with LAMA1 (laminin1) mutation in Poretti-Boltshauser syndrome. JAMA ophthalmology, 136(1), 96-97.

Kashevarova, A. A., Nazarenko, L. P., Skryabin, N. A., Nikitina, T. V., Vasilyev, S. A., Tolmacheva, E. N., ... & Lebedev, I. N. (2018). A mosaic intragenic microduplication of LAMA1 and a constitutional 18p11. 32 microduplication in a patient with keratosis pilaris and intellectual disability. American Journal of Medical Genetics Part A, 176(11), 2395-2403.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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