Human LAMC1 ELISA Kit (V2LY-0626-LY4793)

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Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.14 ng/mL
Detection Range
0.3-90 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
177.6 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
LAMC1
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Biological Process
Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Cell adhesionManual Assertion Based On ExperimentIDA:HGNC-UCL
Cell migrationManual Assertion Based On ExperimentIMP:HGNC-UCL
Endoderm developmentManual Assertion Based On ExperimentTAS:ProtInc
Extracellular matrix disassemblyManual Assertion Based On ExperimentIMP:HGNC-UCL
Hemidesmosome assemblyManual Assertion Based On ExperimentIMP:HGNC-UCL
Maintenance of blood-brain barrier1 PublicationNAS:ARUK-UCL
Positive regulation of epithelial cell proliferationManual Assertion Based On ExperimentTAS:HGNC-UCL
Protein-containing complex assemblyManual Assertion Based On ExperimentIDA:HGNC-UCL
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIDA:BHF-UCL
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted, extracellular space, extracellular matrix, basement membrane

Bai, J., Zheng, A., Ha, Y., Xu, X., Yu, Y., Lu, Y., ... & Jie, W. (2022). Comprehensive analysis of LAMC1 expression and prognostic value in kidney renal papillary cell carcinoma and clear cell carcinoma. Frontiers in Molecular Biosciences, 9, 988777.

Wang, Z., Jiao, P., Zhong, Y., Ji, H., Zhang, Y., Song, H., ... & Wu, H. (2022). The endoplasmic reticulum-stressed head and neck squamous cell carcinoma cells induced exosomal miR-424-5p inhibits angiogenesis and migration of humanumbilical vein endothelial cells through LAMC1-mediated Wnt/β-catenin signaling pathway. Cell Transplantation, 31, 09636897221083549.

Fang, Y., Dou, R., Huang, S., Han, L., Fu, H., Yang, C., ... & Xiong, B. (2022). LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis. International Journal of Biological Sciences, 18(7), 3082.

Wang, Y. Q., Huang, G., Chen, J., Cao, H., & Xu, W. T. (2021). LncRNA SNHG6 promotes breast cancer progression and epithelial-mesenchymal transition via miR-543/LAMC1 axis. Breast Cancer Research and Treatment, 188, 1-14.

Fang, L., Che, Y., Zhang, C., Huang, J., Lei, Y., Lu, Z., ... & He, J. (2021). LAMC1 upregulation via TGFβ induces inflammatory cancer‐associated fibroblasts in esophageal squamous cell carcinoma via NF‐κB–CXCL1–STAT3. Molecular oncology, 15(11), 3125-3146.

Zhi-Rong, H. A. N., Jiang, X. L., & Wen-Chuan, F. A. N. (2021). LAMC1 is related to the poor prognosis of patients with gastric cancer and facilitates cancer cell malignancies. Neoplasma, 68(4).

Kunitomi, H., Kobayashi, Y., Wu, R. C., Takeda, T., Tominaga, E., Banno, K., & Aoki, D. (2020). LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer. Journal of gynecologic oncology, 31(2).

Liu, J., Liu, D., Yang, Z., & Yang, Z. (2019). High LAMC1 expression in glioma is associated with poor prognosis. OncoTargets and therapy, 12, 4253.

Ye, G., Qin, Y., Wang, S., Pan, D., Xu, S., Wu, C., ... & Shen, H. (2019). Lamc1 promotes the Warburg effect in hepatocellular carcinoma cells by regulating PKM2 expression through AKT pathway. Cancer biology & therapy, 20(5), 711-719.

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For research use only. Not intended for any clinical use.

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