Human MVD ELISA Kit (V2LY-0626-LY3979)

Name: Human MVD ELISA Kit
SKU: V2LY-0626-LY3979
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.026 ng/mL

Detection Range

0.05-30 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

43.4 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Mevalonate Diphosphate Decarboxylase

Function

Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

Biological Process

Cholesterol biosynthetic process Source: UniProtKB
Isopentenyl diphosphate biosynthetic process, mevalonate pathway Source: GO_Central
Isoprenoid biosynthetic process Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB

Cellular Location

Cytoplasm

Involvement in disease

Porokeratosis 7, multiple types (POROK7):
A form of porokeratosis, a disorder of faulty keratinization characterized by one or more atrophic patches surrounded by a distinctive hyperkeratotic ridgelike border called the cornoid lamella. The keratotic lesions can progress to overt cutaneous neoplasms, typically squamous cell carcinomas. Multiple clinical variants of porokeratosis are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis. Different clinical presentations can be observed among members of the same family. Individuals expressing more than one variant have also been reported.

La, Y., Wong, W., Peng, K., Tian, Z., Pan, J., Sun, R., ... & Zhang, Z. (2023). Decreased Imiquimod-Induced Psoriasis-Like Skin Inflammation in a Novel Mvd F250S/+ Knock-In Mouse Model. Inflammation, 1-12.

Qian, W., Wu, J., Tang, H., Zhen, Q., Ge, H., Gao, J., ... & Sun, L. (2021). Mutation analysis of the MVD gene in a chinese family with disseminated superficial actinic porokeratosis and a chinese literature review. Indian Journal of Dermatology, 66(2), 126.

Sun, Y., Niu, Y., Huang, H., He, B., Ma, L., Tu, Y., ... & Hu, Z. (2019). Mevalonate diphosphate decarboxylase MVD/Erg19 is required for ergosterol biosynthesis, growth, sporulation and stress tolerance in Aspergillus oryzae. Frontiers in Microbiology, 10, 1074.

Hu, Z., Huang, H., Sun, Y., Niu, Y., Xu, W., Liu, Q., ... & Zeng, B. (2019). Effects on gene transcription profile and fatty acid composition by genetic modification of mevalonate diphosphate decarboxylase MVD/Erg19 in Aspergillus Oryzae. Microorganisms, 7(9), 342.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

MVD Matched Antibody Pair (765) (CAT#: APMAB-765LY)

Antibody Pairs

MVD Matched Antibody Pair (765) (CAT#: APMAB-765LY)

Related Products

Mouse Anti-MVD (AA 301-399) Recombinant Antibody (CBFYM-2838) (CAT#: CBMAB-M3031-FY)

MVD Matched Antibody Pair (765) (CAT#: APMAB-765LY)

Mouse Anti-MVD Recombinant Antibody (2A7) (CAT#: CBMAB-A5698-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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