Human PPARGC1A ELISA Kit (3) (V2LY-0626-LY5688)

peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:10713165, PubMed:20005308, PubMed:21376232).
Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:10713165, PubMed:20005308, PubMed:21376232).
Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed:10713165, PubMed:20005308, PubMed:21376232).
Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed:10713165, PubMed:20005308, PubMed:21376232).
Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed:16753578, PubMed:23142079).
Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (PubMed:23836911).
Also involved in the integration of the circadian rhythms and energy metabolism (By similarity).
Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity).

Adipose tissue developmentIEA:Ensembl
Brown fat cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Cellular glucose homeostasis1 PublicationNAS:UniProtKB
Cellular respirationManual Assertion Based On ExperimentTAS:UniProtKB
Cellular response to oxidative stressISS:UniProtKB
Circadian regulation of gene expressionISS:UniProtKB
DigestionManual Assertion Based On ExperimentTAS:UniProtKB
Energy homeostasisISS:UniProtKB
Fatty acid oxidation1 PublicationNAS:UniProtKB
GluconeogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Mitochondrion organization1 PublicationNAS:UniProtKB
mRNA processingManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of neuron apoptotic processISS:UniProtKB
Negative regulation of neuron deathManual Assertion Based On ExperimentIGI:UniProtKB
Negative regulation of smooth muscle cell proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Neuron apoptotic processIEA:Ensembl
Positive regulation of ATP biosynthetic processISS:UniProtKB
Positive regulation of cellular respirationIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of fatty acid oxidationManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of gluconeogenesisManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of histone acetylationManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of mitochondrial DNA metabolic processIEA:Ensembl
Positive regulation of mitochondrion organizationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Positive regulation of muscle tissue developmentIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:BHF-UCL
Protein stabilizationManual Assertion Based On ExperimentTAS:UniProtKB
Protein-containing complex assemblyManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of circadian rhythmISS:UniProtKB
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Respiratory electron transport chainISS:UniProtKB
Response to dietary excessIEA:Ensembl
Response to muscle activityISS:BHF-UCL
Response to starvation1 PublicationNAS:UniProtKB
RNA splicingManual Assertion Based On ExperimentTAS:UniProtKB
Temperature homeostasisManual Assertion Based On ExperimentTAS:UniProtKB
Transcription initiation from RNA polymerase II promoterManual Assertion Based On ExperimentTAS:UniProtKB

Isoform 1
Nucleus
Nucleus, PML body
Isoform B4
Nucleus
Isoform B4-8a
Cytoplasm
Nucleus
Isoform B5
Nucleus
Nucleus, PML body
Isoform 9
Nucleus

Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2.
Heavily acetylated by KAT2A/GCN5 under conditions of high nutrients, leading to inactivation of PPARGC1A (PubMed:16753578, PubMed:20005308, PubMed:23142079).
Deacetylated by SIRT1 in low nutrients/high NAD conditions, leading to its activation (PubMed:20005308).
Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation.