Human Recombinant ABI1 protein, GST Tag (V2LY-0526-LY6951)

Name: Human Recombinant ABI1 protein, GST Tag
SKU: V2LY-0526-LY6951
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant ABI1 protein, GST Tag consist of Amino Acid: 443-end and predicts a molecular mass of 34 kDa.

Molecule Mass

34 kDa

Sequence

Amino Acid: 443-end

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

abl interactor 1

Function

May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.

Biological Process

Actin polymerization or depolymerization
Fc-gamma receptor signaling pathway involved in phagocytosis
Negative regulation of cell population proliferation
Peptidyl-tyrosine phosphorylation
Transmembrane receptor protein tyrosine kinase signaling pathway
Vascular endothelial growth factor receptor signaling pathway
Viral process

Cellular Location

Cytoskeleton; Nucleus; Cytoplasm; Lamellipodium; Filopodium; Growth cone; Postsynaptic density. Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity).

Involvement in disease

A chromosomal aberration involving ABI1 is a cause of acute leukemias. Translocation t(10;11)(p11.2;q23) with KMT2A/MLL1. ABI1 isoform 2 was found to be present in acute leukemia KMT2A/MLL1-ABI1 fusion transcript.

PTM

Phosphorylated on tyrosine residues after serum stimulation or induction by v-Abl. Seems to be phosphorylated at Tyr-53 by ABL1, required for nuclear but not for synaptic localization.

Li, K., Peng, Y. F., Guo, J. Z., Li, M., Zhang, Y., Chen, J. Y., ... & Yu, W. D. (2021). Abelson interactor 1 splice isoform-L plays an anti-oncogenic role in colorectal carcinoma through interactions with WAVE2 and full-length Abelson interactor 1. World Journal of Gastroenterology, 27(15), 1595.

Zhang, Y., Zhong, Z., Li, M., Chen, J., Lin, T., Sun, J., ... & Yu, W. (2021). The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer. Scientific reports, 11(1), 1-15.

Faulkner, J., Jiang, P., Farris, D., Walker, R., & Dai, Z. (2020). CRISPR/CAS9-mediated knockout of Abi1 inhibits p185 Bcr-Abl-induced leukemogenesis and signal transduction to ERK and PI3K/Akt pathways. Jour

Wang, R., Liao, G., Wang, Y., & Tang, D. D. (2020). Distinctive roles of Abi1 in regulating actin-associated proteins during human smooth muscle cell migration. Scientific reports, 10(1), 1-13.

Qi, Y., Liu, J., Chao, J., Scheuerman, M. P., Rahimi, S. A., Lee, L. Y., & Li, S. (2020). PTEN suppresses epithelial–mesenchymal transition and cancer stem cell activity by downregulating Abi1. Scientific reports, 10(1), 1-13.

Zhou, X., Li, C. H., He, P., Wu, L. F., Lu, X., Lei, S. F., & Deng, F. Y. (2019). Abl interactor 1: A novel biomarker for osteoporosis in Chinese elderly men. Journal of proteomics, 207, 103440.

Chorzalska, A., Morgan, J., Ahsan, N., Treaba, D. O., Olszewski, A. J., Petersen, M., ... & Dubielecka, P. M. (2018). Bone marrow–specific loss of ABI1 induces myeloproliferative neoplasm with features resembling human myelofibrosis. Blood, The Journal of the American Society of Hematology, 132(19), 2053-2066.

Jiang, P., Tang, H., Hogan, H., Tate, S., Ryan, W., Paul, L., ... & Zonghan, D. (2017). Abstract P6-01-14: Dissection of the Abl interactor 1 signaling in metastatic breast cancer cells.

Wang, J. L., Yan, T. T., Long, C., & Cai, W. W. (2017). Oncogenic function and prognostic significance of Abelson interactor 1 in hepatocellular carcinoma. International journal of oncology, 50(5), 1889-1898.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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