Human Recombinant BCL2L11 protein, His Tag (V2LY-0526-LY2356)

BCL2 Like 11

Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.

Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Apoptotic process Source: UniProtKB
Apoptotic process involved in embryonic digit morphogenesis Source: Ensembl
B cell apoptotic process Source: Ensembl
B cell homeostasis Source: Ensembl
Brain development Source: Ensembl
Cell-matrix adhesion Source: Ensembl
Cellular response to amyloid-beta Source: Ensembl
Cellular response to estradiol stimulus Source: Ensembl
Cellular response to glucocorticoid stimulus Source: ARUK-UCL
Cytokine-mediated signaling pathway Source: Reactome
Developmental pigmentation Source: Ensembl
Ear development Source: Ensembl
Extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
Intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
In utero embryonic development Source: Ensembl
Kidney development Source: Ensembl
Male gonad development Source: Ensembl
Mammary gland development Source: Ensembl
Meiosis I Source: GO_Central
Myeloid cell homeostasis Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of apoptotic process by virus Source: Ensembl
Positive regulation of autophagy in response to ER overload Source: Ensembl
Positive regulation of cell cycle Source: Ensembl
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of fibroblast apoptotic process Source: UniProtKB
Positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
Positive regulation of IRE1-mediated unfolded protein response Source: ParkinsonsUK-UCL
Positive regulation of neuron apoptotic process Source: Ensembl
Positive regulation of protein-containing complex assembly Source: BHF-UCL
Positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
Post-embryonic animal organ morphogenesis Source: Ensembl
Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
Regulation of apoptotic process Source: ARUK-UCL
Regulation of developmental pigmentation Source: Ensembl
Regulation of organ growth Source: Ensembl
Response to endoplasmic reticulum stress Source: UniProtKB
Spermatogenesis Source: Ensembl
Spleen development Source: Ensembl
T cell homeostasis Source: Ensembl
Thymocyte apoptotic process Source: Ensembl
Thymus development Source: Ensembl
Tube formation Source: Ensembl

Endomembrane system. Associated with intracytoplasmic membranes.
Isoform BimEL: Mitochondrion. Translocates from microtubules to mitochondria on loss of cell adherence.
Isoform BimL: Mitochondrion.
Isoform BimS: Mitochondrion
Isoform Bim-alpha1: Mitochondrion

Phosphorylation at Ser-69 by MAPK1/MAPK3 leads to interaction with TRIM2 and polyubiquitination, followed by proteasomal degradation (PubMed:15486195, PubMed:21478148). Deubiquitination catalyzed by USP27X stabilizes the protein (By similarity).
Ubiquitination by TRIM2 following phosphorylation by MAPK1/MAPK3 leads to proteasomal degradation. Conversely, deubiquitination catalyzed by USP27X stabilizes the protein.