Human Recombinant CD98 protein, AF647 Conjugated, His Tag (V2LY-0526-LY2984)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
The precise substrate specificity depends on the other subunit in the heterodimer (PubMed:9829974, PubMed:9751058, PubMed:10391915, PubMed:10574970, PubMed:30867591, PubMed:10903140).
The complexes function as amino acid exchangers (PubMed:11557028, PubMed:10903140, PubMed:12117417, PubMed:12225859, PubMed:30867591).
The homodimer functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:11557028, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591).
The heterodimer formed by SLC3A2 and SLC7A6 or SLC3A2 and SLC7A7 mediates the uptake of dibasic amino acids (PubMed:9829974, PubMed:10903140).
The heterodimer with SLC7A5/LAT1 mediates the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859).
The heterodimer with SLC7A5/LAT1 is involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417).
The heterodimer with SLC7A5/LAT1 is involved in the uptake of leucine (PubMed:25998567, PubMed:30341327).
When associated with LAPTM4B, the heterodimer with SLC7A5/LAT1 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567).
The heterodimer with SLC7A5/LAT1 may play a role in the transport of L-DOPA across the blood-brain barrier (By similarity).
The heterodimer formed by SLC3A2 and SLC7A5/LAT1 or SLC3A2 and SLC7A8/LAT2 is involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (PubMed:15769744).
Together with ICAM1, regulates the transport activity of SLC7A8/LAT2 in polarized intestinal cells by generating and delivering intracellular signals (PubMed:12716892).
Required for targeting of SLC7A5/LAT1 and SLC7A8/LAT2 to the plasma membrane and for channel activity (PubMed:9751058, PubMed:11311135, PubMed:30867591).
Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine (PubMed:14603368).
May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity).
(Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis.
Biological Process calcium ion transport1 PublicationNAS:UniProtKB
Biological Process carbohydrate metabolic processIEA:InterPro
Biological Process L-alanine import across plasma membraneManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process L-leucine import across plasma membraneManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process leucine import across plasma membraneManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process leucine transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process phenylalanine transportManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process response to exogenous dsRNAManual Assertion Based On ExperimentIMP:MGI
Biological Process tryptophan transportISS:UniProtKB
Biological Process viral entry into host cellManual Assertion Based On ExperimentIMP:UniProtKB
Helical: 185-205
Extracellular: 206-630
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Cynomolgus Recombinant CD98 protein, ECD, His Tag (CAT#: V2LY-0526-LY1460)
Human Recombinant CD98 protein, AF488 Conjugated, His Tag (CAT#: V2LY-0526-LY2983)
Human Recombinant CD98 protein, APC Conjugated, His Tag (CAT#: V2LY-0526-LY2985)
Human Recombinant CD98 protein, ECD, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY2986)
Human Recombinant CD98 protein, His Tag (CAT#: V2LY-0526-LY2987)
Human Recombinant CD98 protein, His Tag-1 (CAT#: V2LY-0526-LY2988)
Human Recombinant CD98 protein, His Tag-2 (CAT#: V2LY-0526-LY2989)
Human Recombinant CD98 protein, PE Conjugated, His Tag (CAT#: V2LY-0526-LY2990)
Mouse Recombinant CD98 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY8082)
Antibody Pairs
SLC3A2 Matched Antibody Pair (1099) (CAT#: APMAB-1099LY)
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Mouse Recombinant CD98 protein, His Tag (CAT#: V2LY-0526-LY8083)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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