Human Recombinant CILK1, Active protein, GST Tag (V2LY-0526-LY4633)

Name: Human Recombinant CILK1, Active protein, GST Tag
SKU: V2LY-0526-LY4633
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant CILK1, Active protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 98 kDa.

Molecule Mass

98 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

ciliogenesis associated kinase 1

Alternative Names

ECO; ICK; MRK; CED6; LCK2; hICK; EJM10

Function

Required for ciliogenesis. Phosphorylates KIF3A. Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity).

Biological Process

Cilium assemblySource:UniProtKB
Intracellular signal transductionSource:UniProtKB
Intraciliary anterograde transportSource:UniProtKB
Intraciliary retrograde transportSource:UniProtKB
Intraciliary transportSource:UniProtKB
Protein phosphorylationSource:UniProtKB
Signal transduction

Cellular Location

Nucleus; Cytoplasm, cytosol; Cell projection, cilium; Cytoplasm, cytoskeleton, cilium basal body

Involvement in disease

ECO: Previously unidentified neonatal lethal recessive disorder with multiple anomalies involving the endocrine, cerebral, and skeletal systems.
Juvenile myoclonic epilepsy 10 (EJM10): A form of juvenile myoclonic epilepsy, a subtype of idiopathic generalized epilepsy generally characterized by afebrile seizures with onset in adolescence (rather than in childhood) and myoclonic jerks, which usually occur after awakening and are triggered by sleep deprivation and fatigue. EJM10 is an autosomal dominant seizure disorder with variable manifestations, even within families. Affected individuals have febrile, myoclonic, tonic-clonic, or absence seizures, although several seizure types can occur in the same individual. Some patients have onset of seizures in the first years of life.
Cranioectodermal dysplasia 6 (CED6): A form of cranioectodermal dysplasia, a disorder primarily characterized by craniofacial, skeletal and ectodermal abnormalities. CED6 is an autosomal recessive form characterized by dolichocephaly, relative macrocephaly due to external hydrocephalus, dysmorphic facial features, growth retardation, skeletal anomalies, joint laxity, sparse hair, sparse eyebrows and eyelashes, and dental abnormalities. Renal and hepatic abnormalities have also been observed.

PTM

Autophosphorylated on serine and threonine residues. Phosphorylation at Thr-157 increases kinase activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-CILK1 Recombinant Antibody (EG1602) (CAT#: CBMAB-EN1916-LY)

Isotype control

For research use only. Not intended for any clinical use.

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