Human Recombinant CLK4, Active protein, GST Tag (V2LY-0526-LY3232)

Name: Human Recombinant CLK4, Active protein, GST Tag
SKU: V2LY-0526-LY3232
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant CLK4, Active protein, GST Tag consist of Amino Acid: 70-end and predicts a molecular mass of 73 kDa.

Molecule Mass

73 kDa

Sequence

Amino Acid: 70-end

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

CDC Like Kinase 4

Function

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

Biological Process

Protein autophosphorylation Source: Ensembl
Regulation of RNA splicing Source: UniProtKB

Cellular Location

Nucleus

PTM

Autophosphorylates on all three types of residues.

Kang, E., Kim, S., Jeon, S. Y., Jung, J. G., Kim, H. K., Lee, H. B., & Han, W. (2022). Targeting CLK4 inhibits the metastasis and progression of breast cancer by inactivating TGF-β pathway. Cancer Gene Therapy, 1-13.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CLK4 (I363V), Active protein, GST Tag (CAT#: V2LY-0526-LY3233)

Related Products

Human Recombinant CLK4 (I363V), Active protein, GST Tag (CAT#: V2LY-0526-LY3233)

Mouse Anti-CLK4 Recombinant Antibody (EG733) (CAT#: V2LY-1206-LY252)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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