Human Recombinant CXCL13 protein (V2LY-0526-LY2302)

Name: Human Recombinant CXCL13 protein
SKU: V2LY-0526-LY2302
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Protein Construction

This product is Human Recombinant CXCL13 protein consist of Amino Acid: 23-94 and predicts a molecular mass of 8.8 kDa.

Molecule Mass

8.8 kDa

Sequence

Amino Acid: 23-94

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

C-X-C Motif Chemokine Ligand 13

Function

Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.

Biological Process

Activation of GTPase activity Source: BHF-UCL
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
B cell chemotaxis Source: BHF-UCL
Cell-cell signaling Source: BHF-UCL
Cell surface receptor signaling pathway Source: BHF-UCL
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chronic inflammatory response Source: BHF-UCL
Defense response to bacterium Source: BHF-UCL
Endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
Germinal center formation Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: BHF-UCL
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis across high endothelial venule Source: BHF-UCL
Negative regulation of endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
Neutrophil chemotaxis Source: GO_Central
Positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
Positive regulation of integrin activation Source: BHF-UCL
Positive regulation of T cell chemotaxis Source: BHF-UCL
Regulation of angiogenesis Source: BHF-UCL
Regulation of humoral immune response Source: BHF-UCL

Cellular Location

Secreted

Perreau, M., Suffiotti, M., Marques-Vidal, P., Wiedemann, A., Levy, Y., Laouénan, C., ... & Pantaleo, G. (2021). The cytokines HGF and CXCL13 predict the severity and the mortality in COVID-19 patients. Nature Communications, 12(1), 1-10.

Chen, F., Li, X., Li, Z., Zhou, Y., Qiang, Z., & Ma, H. (2020). The roles of chemokine (CXC motif) ligand 13 in spinal cord ischemia-reperfusion injury in rats. Brain Research, 1727, 146489.

Hussain, M., Adah, D., Tariq, M., Lu, Y., Zhang, J., & Liu, J. (2019). CXCL13/CXCR5 signaling axis in cancer. Life sciences, 227, 175-186.

Zhu, L., Zhang, G., Wang, P., Zhang, L., Ji, J., Liu, X., ... & Wang, X. (2019). The effect of CXC motif chemokine ligand 13 in cutaneous squamous cell carcinoma treated with aminolevulinic acid-photodynamic therapy. Photodiagnosis and Photodynamic Therapy, 26, 389-394.

Kazanietz, M. G., Durando, M., & Cooke, M. (2019). CXCL13 and its receptor CXCR5 in cancer: inflammation, immune response, and beyond. Frontiers in endocrinology, 10, 471.

Wei, Y., Lin, C., Li, H., Xu, Z., Wang, J., Li, R., ... & Xu, J. (2018). CXCL13 expression is prognostic and predictive for postoperative adjuvant chemotherapy benefit in patients with gastric cancer. Cancer Immunology, Immunotherapy, 67(2), 261-269.

Wagner, J. N., Weis, S., Kubasta, C., Panholzer, J., & von Oertzen, T. J. (2018). CXCL13 as a diagnostic marker of neuroborreliosis and other neuroinflammatory disorders in an unselected group of patients. Journal of Neurology, 265(1), 74-81.

Xu, L., Liang, Z., Li, S., & Ma, J. (2018). Signaling via the CXCR5/ERK pathway is mediated by CXCL13 in mice with breast cancer. Oncology Letters, 15(6), 9293-9298.

Meng, X., Yu, X., Dong, Q., Xu, X., Li, J., Xu, Q., ... & Zhou, C. (2018). Distribution of circulating follicular helper T cells and expression of interleukin‑21 and chemokine C‑X‑C ligand 13 in gastric cancer. Oncology Letters, 16(3), 3917-3922.

Pietikäinen, A., Oksi, J., & Hytönen, J. (2018). Point-of-care testing for CXCL13 in Lyme neuroborreliosis. Diagnostic Microbiology and Infectious Disease, 91(3), 226-228.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant CXCL13 protein, His Tag (CAT#: V2LY-0526-LY1206)

Cynomolgus Recombinant BCA-1/CXCL13 protein, His Tag (CAT#: V2LY-0526-LY1391)

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Rat Anti-CXCL13 Recombinant Antibody (C11362) (CAT#: CBMAB-C11362-LY)

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Canine Recombinant CXCL13 protein, His Tag (CAT#: V2LY-0526-LY1206)

Mouse Anti-CXCL13 Recombinant Antibody (14L309) (CAT#: V2LY-0125-LY664)

Mouse Anti-CXCL13 Recombinant Antibody (MA076) (CAT#: V2LY-0125-LY667)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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