Human Recombinant GMFB protein (V2LY-0526-LY4366)

Name: Human Recombinant GMFB protein
SKU: V2LY-0526-LY4366
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Protein Construction

This product is Human Recombinant GMFB protein consist of Amino Acid: 1-142 and predicts a molecular mass of 16.7 kDa.

Molecule Mass

16.7 kDa

Sequence

Amino Acid: 1-142

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Glia Maturation Factor Beta

Function

This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.

Biological Process

Actin filament debranching Source: GO_Central
Negative regulation of Arp2/3 complex-mediated actin nucleation Source: GO_Central
Nervous system development Source: ProtInc
Protein phosphorylation Source: ProtInc

PTM

Phosphorylated; stimulated by phorbol ester.

Liu, C., Sun, W., Zhu, T., Shi, S., Zhang, J., Wang, J., ... & Lu, L. (2022). Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy. Redox Biology, 52, 102292.

Yin, G., Zeng, W., Li, R., Zeng, M., Chen, R., Liu, Y., ... & Wang, Y. (2022). Glia Maturation Factor-β Supports Liver Regeneration by Remodeling Actin Network to Enhance STAT3 Proliferative Signals. Cellular and Molecular Gastroenterology and Hepatology, 14(5), 1123-1145.

Zhu, T., Wang, T., Feng, Z., Gao, F., Zhang, J., Jin, C., ... & Lu, L. (2022). Glia Maturation Factor β as a Novel Independent Prognostic Biomarker and Potential Therapeutic Target of Kidney Renal Clear Cell Carcinoma. Frontiers in Oncology, 12.

Sun, W., Hu, C., Wang, T., Wang, J., Zhang, J., Gao, F., ... & Lu, L. (2021). Glia maturation factor beta as a novel biomarker and therapeutic target for hepatocellular carcinoma. Frontiers in Oncology, 11, 744331.

Teruya, K., Oguma, A., Arai, K., Nishizawa, K., Iwabuchi, S., Watanabe-Matsui, M., ... & Doh-Ura, K. (2021). Polymorphisms in glia maturation factor β gene are markers of cellulose ether effectiveness in prion-infected mice. Biochemical and biophysical research communications, 560, 105-111.

Wang, J., Awuti, M., Jiang, X., Zhang, J., Lyu, Y., Lu, L., & Xu, G. T. (2018). Effect of Glia Maturation Factor beta (GMFB) on Retinal Pigment Epithelium in Diabetic Retinopathy. Investigative Ophthalmology & Visual Science, 59(9), 3979-3979.

Xu, F. F., Zhang, Z. B., Wang, Y. Y., & Wang, T. H. (2018). Brain-derived glia maturation factor β participates in lung injury induced by acute cerebral ischemia by increasing ROS in endothelial cells. Neuroscience bulletin, 34, 1077-1090.

Yin, G., Du, M., Li, R., Li, K., Huang, X., Duan, D., ... & Wu, B. (2018). Glia maturation factor beta is required for reactive gliosis after traumatic brain injury in zebrafish. Experimental Neurology, 305, 129-138.

Fan, J., Fong, T., Chen, X., Chen, C., Luo, P., & Xie, H. (2018). Glia maturation factor-β: A potential therapeutic target in neurodegeneration and neuroinflammation. Neuropsychiatric disease and treatment, 495-504.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-GMFB Recombinant Antibody (D8) (CAT#: CBMAB-G0556-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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