Human Recombinant IL1RL2 protein, hFc Tag (V2LY-0526-LY4822)

Name: Human Recombinant IL1RL2 protein, hFc Tag
SKU: V2LY-0526-LY4822
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant IL1RL2 protein, hFc Tag consist of Amino Acid: 1-337 and predicts a molecular mass of 63.2 kDa.

Molecule Mass

63.2 kDa

Verified

HPLC

Sequence

Amino Acid: 1-337

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

interleukin 1 receptor-like 2

Function

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity).
The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.

Cellular Location

Membrane

Topology

Extracellular: 20-335
Helical: 336-356
Cytoplasmic: 357-575

Kurose, S., Matsubara, Y., Yoshino, S., Yoshiya, K., Morisaki, K., Furuyama, T., ... & Yoshizumi, T. (2023). Interleukin‐38 suppresses abdominal aortic aneurysm formation in mice by regulating macrophages in an IL1RL2‐p38 pathway‐dependent manner. Physiological Reports, 11(2), e15581.

Husain, H., Waseem, M., & Ahmad, R. (2021). Proteomic and molecular evidences of Il1rl2, Ric8a, Krt18 and Hsp90b1 modulation during experimental hepatic fibrosis and pomegranate supplementation. International Journal of Biological Macromolecules, 185, 696-707.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant IL1RL2 protein, ECD, His Tag (CAT#: V2LY-0526-LY1564)

Human Recombinant IL1RL2 protein, His Tag (CAT#: V2LY-0526-LY4823)

Related Products

Human Recombinant IL1RL2 protein, His Tag (CAT#: V2LY-0526-LY4823)

Mouse Anti-IL1RL2 Recombinant Antibody (ABM47A2) (CAT#: CBMAB-I1875-YY)

Cynomolgus Recombinant IL1RL2 protein, ECD, His Tag (CAT#: V2LY-0526-LY1564)

Mouse Anti-IL1RL2 Recombinant Antibody (CBYY-I1096) (CAT#: CBMAB-I2264-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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