IL1RL2

The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq]
Full Name
interleukin 1 receptor-like 2
Function
Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity).
The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
Cellular Location
Membrane
Topology
Extracellular: 20-335
Helical: 336-356
Cytoplasmic: 357-575
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Anti-IL1RL2 antibodies

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Human Recombinant IL1RL2 protein, His Tag (V2LY-0526-LY4823)

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Target: IL1RL2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-337
Tag: His Tag
Datasheet SDS

Cynomolgus Recombinant IL1RL2 protein, ECD, His Tag (V2LY-0526-LY1564)

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Target: IL1RL2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-335
Tag: His Tag
Datasheet SDS

Human Recombinant IL1RL2 protein, hFc Tag (V2LY-0526-LY4822)

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Target: IL1RL2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-337
Tag: hFc Tag
Datasheet SDS

Mouse Anti-IL1RL2 Recombinant Antibody (CBYY-I1096) (CBMAB-I2264-YY)

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Target: IL1RL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1096
Application*: WB
Datasheet SDS

Mouse Anti-IL1RL2 Recombinant Antibody (ABM47A2) (CBMAB-I1875-YY)

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Target: IL1RL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: ABM47A2
Application*: WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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