Human Recombinant LRRC4C protein, His Tag (V2LY-0526-LY5785)

Name: Human Recombinant LRRC4C protein, His Tag
SKU: V2LY-0526-LY5785
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant LRRC4C protein, His Tag consist of Amino Acid: 1-527 and predicts a molecular mass of 55.51 kDa.

Molecule Mass

55.51 kDa

Verified

HPLC

Sequence

Amino Acid: 1-527

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

leucine rich repeat containing 4C

Function

May promote neurite outgrowth of developing thalamic neurons.

Biological Process

Modulation of chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of axonogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Synaptic membrane adhesionManual Assertion Based On ExperimentIGI:SynGO-UCL

Cellular Location

Cell junction, synapse, postsynaptic cell membrane

Topology

Helical: 528-548

Rajabli, F., Benchek, P., Tosto, G., Kushch, N., Sha, J., Bazemore, K., ... & Lerner, A. (2023). Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK, GRB14, and KIAA0825 as novel risk loci for Alzheimer disease: the Alzheimer Disease Genetics Consortium. medRxiv, 2023-07.

Clark, R., Pozarickij, A., Hysi, P. G., Ohno-Matsui, K., Williams, C., Guggenheim, J. A., & UK Biobank Eye and Vision Consortium. (2022). Education interacts with genetic variants near GJD2, RBFOX1, LAMA2, KCNQ5 and LRRC4C to confer susceptibility to myopia. PLoS Genetics, 18(11), e1010478.

Naj, A. C., Reitz, C., Rajabli, F., Jun, G. R., Benchek, P., Tosto, G., ... & Alzheimer’s Disease Genetics Consortium (ADGC). (2022). Multi‐Ancestry Genome‐wide Association Analysis of Late‐Onset Alzheimer’s Disease (LOAD) in 60,941 Individuals Identifies a Novel Cross‐Ancestry Association in LRRC4C. Alzheimer's & Dementia, 18, e065822.

Foss-Skiftesvik, J., Hagen, C. M., Mathiasen, R., Adamsen, D., Bækvad-Hansen, M., Børglum, A. D., ... & Bybjerg-Grauholm, J. (2021). Genome-wide association study across pediatric central nervous system tumors implicates shared predisposition and points to 1q25. 2 (PAPPA2) and 11p12 (LRRC4C) as novel candidate susceptibility loci. Child's Nervous System, 37, 819-830.

Yang, X., Lei, P., Huang, L., Tang, X., Wei, B., & Wei, H. (2021). Prognostic value of LRRC4C in colon and gastric cancers correlates with tumour microenvironment immunity. International Journal of Biological Sciences, 17(5), 1413.

Choi, Y., Park, H., Kang, S., Jung, H., Kweon, H., Kim, S., ... & Kim, E. (2019). NGL-1/LRRC4C-mutant mice display hyperactivity and anxiolytic-like behavior associated with widespread suppression of neuronal activity. Frontiers in Molecular Neuroscience, 12, 250.

Choi, Y., Park, H., Jung, H., Kweon, H., Kim, S., Lee, S. Y., ... & Kim, E. (2019). NGL-1/LRRC4C deletion moderately suppresses hippocampal excitatory synapse development and function in an input-independent manner. Frontiers in Molecular Neuroscience, 12, 119.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant LRRC4C protein, ECD, His Tag (CAT#: V2LY-0526-LY8705)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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