Human Recombinant LTK, Active protein, GST Tag (V2LY-0526-LY5395)

Name: Human Recombinant LTK, Active protein, GST Tag
SKU: V2LY-0526-LY5395
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant LTK, Active protein, GST Tag consist of Amino Acid: 450-864 and predicts a molecular mass of 70 kDa.

Molecule Mass

70 kDa

Sequence

Amino Acid: 450-864

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Sodium phosphate, NaCl, Imidazole, DTT, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Leukocyte Receptor Tyrosine Kinase

Function

Receptor with a tyrosine-protein kinase activity (PubMed:10445845, PubMed:20548102, PubMed:30061385).
Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:30061385, PubMed:34646012).
Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:20548102).
Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (By similarity).
The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival (PubMed:9223670, PubMed:18849880).
Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (PubMed:20548102).

Biological Process

Cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to retinoic acidManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cardiac muscle cell apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of neuron projection developmentManual Assertion Based On ExperimentIMP:BHF-UCL
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Involvement in disease

Genetic variations in LTK that cause up-regulation of the PI3K pathway may possibly contribute to susceptibility to abnormal proliferation of self-reactive B-cells and, therefore, to systemic lupus erythematosus (SLE) (PubMed:14695357). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue, thought to represent a failure of the regulatory mechanisms of the autoimmune system (PubMed:14695357).

Topology

Extracellular: 17-424
Helical: 425-449
Cytoplasmic: 450-864

PTM

Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity.

Kabangu, M., Cecil, R., Strohl, L., Timoshevskaya, N., Smith, J. J., & Voss, S. R. (2023). Leukocyte Tyrosine Kinase (Ltk) Is the Mendelian Determinant of the Axolotl Melanoid Color Variant. Genes, 14(4), 904.

Ibrahim, R., Chahine, C., Felefly, T., Khalife, N., & Saleh, K. (2023). The CLIP1–LTK fusion: a new oncogenic driver in non-small-cell lung cancer?. Future Oncology, 19(4), 273-275.

Cooper, A. J., Sequist, L. V., Johnson, T. W., & Lin, J. J. (2022). LTK fusions: A new target emerges in non-small cell lung cancer. Cancer cell, 40(1), 23-25.

Centonze, F. G. (2020). Elucidation of the receptor tyrosine kinase LTK as a regulator of Proteostasis in response to folded proteins.

Creeden, J. F., Alganem, K., Imami, A. S., Brunicardi, F. C., Liu, S. H., Shukla, R., ... & McCullumsmith, R. E. (2020). Kinome array profiling of patient-derived pancreatic ductal adenocarcinoma identifies differentially active protein tyrosine kinases. International journal of molecular sciences, 21(22), 8679.

Centonze, F. G., Reiterer, V., Nalbach, K., Saito, K., Pawlowski, K., Behrends, C., & Farhan, H. (2019). LTK is an ER-resident receptor tyrosine kinase that regulates secretion. Journal of Cell Biology, 218(8), 2470-2480.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rabbit Anti-LTK (Phosphorylated Y672) Recombinant Antibody (CAT#: PTM-CBMAB-0219LY)

Related Products

Rabbit Anti-LTK (Phosphorylated Y672) Recombinant Antibody (CAT#: PTM-CBMAB-0219LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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