Human Recombinant MVK protein, GST Tag (V2LY-0526-LY5668)

Name: Human Recombinant MVK protein, GST Tag
SKU: V2LY-0526-LY5668
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant MVK protein, GST Tag consist of Amino Acid: 1-396 and predicts a molecular mass of 70.2 kDa.

Molecule Mass

70.2 kDa

Sequence

Amino Acid: 1-396

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Mevalonate Kinase

Function

Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:9325256, PubMed:18302342, PubMed:9392419, PubMed:11278915).

Biological Process

Cholesterol biosynthetic process Source: UniProtKB
Isopentenyl diphosphate biosynthetic process, mevalonate pathway Source: GO_Central
Isoprenoid biosynthetic process Source: UniProtKB
Negative regulation of inflammatory response Source: BHF-UCL

Cellular Location

Cytoplasm
Peroxisome

Involvement in disease

Mevalonic aciduria (MEVA):
Accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia.
Hyperimmunoglobulinemia D and periodic fever syndrome (HIDS):
Autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), arthralgias and/or arthritis. Concentration of IgD, and often IgA, are above normal.
Porokeratosis 3, multiple types (POROK3):
A form of porokeratosis, a disorder of faulty keratinization characterized by one or more atrophic patches surrounded by a distinctive hyperkeratotic ridgelike border called the cornoid lamella. The keratotic lesions can progress to overt cutaneous neoplasms, typically squamous cell carcinomas. Multiple clinical variants of porokeratosis are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis. Different clinical presentations can be observed among members of the same family. Individuals expressing more than one variant have also been reported.

Touitou, I. (2022). Twists and turns of the genetic story of mevalonate kinase-associated diseases: A review. Genes & Diseases, 9(4), 1000-1007.

Elhani, I., Hentgen, V., Grateau, G., & Georgin-Lavialle, S. (2022). Neurological manifestations in mevalonate kinase deficiency: A systematic review. Molecular Genetics and Metabolism, 136(2), 85-93.

Boursier, G., Rittore, C., Milhavet, F., Cuisset, L., & Touitou, I. (2021). Mevalonate kinase-associated diseases: hunting for phenotype–genotype correlation. Journal of Clinical Medicine, 10(8), 1552.

Politiek, F. A., & Waterham, H. R. (2021). Compromised protein prenylation as pathogenic mechanism in mevalonate kinase deficiency. Frontiers in immunology, 3504.

Tabatabaee, S., Iranbakhsh, A., Shamili, M., & Ardebili, Z. O. (2021). Copper nanoparticles mediated physiological changes and transcriptional variations in microRNA159 (miR159) and mevalonate kinase (MVK) in pepper; potential benefits and phytotoxicity assessment. Journal of Environmental Chemical Engineering, 9(5), 106151.

Govindaraj, G. M., Jain, A., Peethambaran, G., Bhoyar, R. C., Vellarikkal, S. K., Ganapati, A., ... & Scaria, V. (2020). Spectrum of clinical features and genetic variants in mevalonate kinase (MVK) gene of South Indian families suffering from Hyperimmunoglobulin D Syndrome. PloS one, 15(8), e0237999.

Munoz, M. A., Jurczyluk, J., Simon, A., Hissaria, P., Arts, R. J., Coman, D., ... & Rogers, M. J. (2019). Defective protein prenylation in a spectrum of patients with mevalonate kinase deficiency. Frontiers in immunology, 10, 1900.

McClory, J., Lin, J. T., Timson, D. J., Zhang, J., & Huang, M. (2019). Catalytic mechanism of mevalonate kinase revisited, a QM/MM study. Organic & Biomolecular Chemistry, 17(9), 2423-2431.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

MVK Matched Antibody Pair (766) (CAT#: APMAB-766LY)

Antibody Pairs

MVK Matched Antibody Pair (766) (CAT#: APMAB-766LY)

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Isotype control

For research use only. Not intended for any clinical use.

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