Human Recombinant NEK8, Active protein, GST Tag (V2LY-0526-LY5743)

Name: Human Recombinant NEK8, Active protein, GST Tag
SKU: V2LY-0526-LY5743
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant NEK8, Active protein, GST Tag consist of Amino Acid: 1-322 and predicts a molecular mass of 66 kDa.

Molecule Mass

66 kDa

Sequence

Amino Acid: 1-322

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

NIMA RELATED KINASE 8

Function

Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity).

Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.

Biological Process

Animal organ morphogenesis Source: UniProtKB
Chromosome segregation Source: GO_Central
Determination of left/right symmetry Source: Ensembl
Heart development Source: Ensembl
Regulation of hippo signaling Source: UniProtKB

Cellular Location

Cytoplasm
Cytoskeleton
centrosome
Other locations
cilium
Note: Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells.

Involvement in disease

Nephronophthisis 9 (NPHP9):
An autosomal recessive disorder resulting in end-stage renal disease. It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts.
Renal-hepatic-pancreatic dysplasia 2 (RHPD2):
A form of renal-hepatic-pancreatic dysplasia, a disease characterized by cystic malformations of the kidneys, liver, and pancreas. The pathological findings consist of multicystic dysplastic kidneys, dilated and dysgenetic bile ducts, a dysplastic pancreas with dilated ducts, cysts, fibrosis and inflammatory infiltrates.

Kang, E., Kim, H. K., Lee, H. B., & Han, W. (2023). Never in mitosis gene A-related kinase-8 promotes proliferation, migration, invasion, and stemness of breast cancer cells via β-catenin signalling activation. Scientific Reports, 13(1), 6829.

Wang, Y. J., Zhao, Y., Sun, Y. W., & Chen, Y. (2022). Never-in-Mitosis A-Related Kinase 8 (NEK8) Regulates Adipogenesis, Glucose Homeostasis, and Obesity. Oxidative Medicine and Cellular Longevity, 2022.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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