Human Recombinant PCSK9 protein, His Tag (V2LY-0526-LY5996)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:18799458, PubMed:17461796, PubMed:18197702, PubMed:22074827).
Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751).
Inhibits epithelial Na+ channel (ENaC)-mediated Na+ absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.
Cellular response to insulin stimulusBy SimilarityISS:HGNC-UCL
Cellular response to starvationBy SimilarityISS:HGNC-UCL
Cholesterol homeostasisManual Assertion Based On ExperimentIMP:HGNC-UCL
Cholesterol metabolic processIEA:UniProtKB-KW
Kidney developmentBy SimilarityISS:HGNC-UCL
Lipoprotein metabolic processIEA:Ensembl
Liver developmentBy SimilarityISS:HGNC-UCL
Low-density lipoprotein particle receptor catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Lysosomal transportManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of low-density lipoprotein particle clearanceManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of low-density lipoprotein particle receptor bindingManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of low-density lipoprotein receptor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of receptor internalizationManual Assertion Based On ExperimentIDA:ComplexPortal
Negative regulation of receptor recyclingManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of receptor-mediated endocytosis involved in cholesterol transportManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of sodium ion transmembrane transporter activityManual Assertion Based On ExperimentIDA:BHF-UCL
NeurogenesisBy SimilarityISS:HGNC-UCL
Neuron differentiationBy SimilarityISS:HGNC-UCL
Phospholipid metabolic processIEA:Ensembl
Positive regulation of low-density lipoprotein particle receptor catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of neuron apoptotic processManual Assertion Based On ExperimentIMP:HGNC-UCL
Positive regulation of receptor internalizationManual Assertion Based On ExperimentIDA:BHF-UCL
Protein autoprocessingManual Assertion Based On ExperimentIDA:HGNC-UCL
Regulation of neuron apoptotic processISS:UniProtKB
Regulation of signaling receptor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Triglyceride metabolic processIEA:Ensembl
Secreted
Endosome
Lysosome
Cell surface
Endoplasmic reticulum
Golgi apparatus
Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation.
A form of hypercholesterolemia, a disorder of lipoprotein metabolism characterized by elevated serum low-density lipoprotein (LDL) cholesterol levels, which result in excess deposition of cholesterol in tissues and leads to xanthelasma, xanthomas, accelerated atherosclerosis and increased risk of premature coronary heart disease. FHCL3 inheritance is autosomal dominant.
Undergoes autocatalytic cleavage in the endoplasmic reticulum to release the propeptide from the N-terminus and the cleavage of the propeptide is strictly required for its maturation and activation. The cleaved propeptide however remains associated with the catalytic domain through non-covalent interactions, preventing potential substrates from accessing its active site. As a result, it is secreted from cells as a propeptide-containing, enzymatically inactive protein.
Phosphorylation protects the propeptide against proteolysis.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Human Recombinant PCSK9 (D374Y) protein, His Tag (CAT#: V2LY-0526-LY5992)
Human Recombinant PCSK9 (D374Y) protein, Biotin Conjugated, Fc Tag (CAT#: V2LY-0526-LY5994)
Human Recombinant PCSK9 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY5995)
Human Recombinant PCSK9 protein, His Tag-1 (CAT#: V2LY-0526-LY5997)
Human Recombinant PCSK9 protein, His Tag-2 (CAT#: V2LY-0526-LY5998)
Human Recombinant PCSK9 protein, Fc Tag (CAT#: V2LY-0526-LY5999)
Mouse Recombinant PCSK9 protein, His Tag (CAT#: V2LY-0526-LY8740)
Mouse Recombinant PCSK9 protein, Fc Tag (CAT#: V2LY-0526-LY8741)
Rat Recombinant PCSK9 protein, His Tag (CAT#: V2LY-0526-LY9540)
Related Products
Rat Anti-PCSK9 Recombinant Antibody (15H129) (CAT#: CBMAB-P1104-YC)
Rabbit Anti-PCSK9 Recombinant Antibody (
7F2) (CAT#: V2LY-0725-LY1128)
Human Recombinant PCSK9 (D374Y) protein, His Tag (CAT#: V2LY-0526-LY5992)
Mouse Recombinant PCSK9 protein, His Tag (CAT#: V2LY-0526-LY8740)
Mouse Anti-PCSK9 Recombinant Antibody (CBXF-0041) (CAT#: CBMAB-F1310-CQ)
Rhesus Recombinant PCSK9 protein, His Tag (CAT#: V2LY-0526-LY9777)
Rat Anti-PCSK9 Recombinant Antibody (CBYC-P228) (CAT#: CBMAB-P1106-YC)
Human Recombinant PCSK9 protein, His Tag-1 (CAT#: V2LY-0526-LY5997)
Human Recombinant PCSK9 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY5995)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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