Human Recombinant PDE2A protein, His Tag (V2LY-0526-LY6029)

phosphodiesterase 2A, cGMP-stimulated

cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:9210593, PubMed:29392776, PubMed:15938621).
Has a higher efficiency with cGMP compared to cAMP (PubMed:15938621).
Plays a role in cell growth and migration (PubMed:24705027).
Isoform PDE2A2
Regulates mitochondrial cAMP levels and respiration (By similarity).
Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107).

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Aorta developmentISS:BHF-UCL
cAMP-mediated signalingManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to 2,3,7,8-tetrachlorodibenzodioxineManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to cAMPManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to cGMPManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to granulocyte macrophage colony-stimulating factor stimulusIDA:UniProtKB
Cellular response to macrophage colony-stimulating factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to mechanical stimulusISS:UniProtKB
Cellular response to transforming growth factor beta stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Cellular response to xenobiotic stimulusIEP:UniProtKB
cGMP catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
cGMP-mediated signalingManual Assertion Based On ExperimentIMP:UniProtKB
Establishment of endothelial barrierISS:UniProtKB
Heart valve developmentISS:BHF-UCL
Monocyte differentiationIEP:UniProtKB
Negative regulation of cAMP-mediated signalingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cGMP-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of vascular permeabilityManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of inflammatory responseISS:UniProtKB
Positive regulation of vascular permeabilityManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cAMP-mediated signalingManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cGMP-mediated signalingManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of mitochondrion organizationManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Ventricular septum developmentISS:BHF-UCL

Isoform PDE2A3
Cell membrane
Isoform PDE2A2
Mitochondrion matrix
Mitochondrion inner membrane
Mitochondrion outer membrane
Isoform PDE2A1
Cytoplasm
Isoform 5
Mitochondrion

Intellectual developmental disorder with paroxysmal dyskinesia or seizures (IDDPADS):
An autosomal recessive disorder characterized by global developmental delay, impaired intellectual development, language delay, and early-onset paroxysmal hyperkinetic movement disorder that manifests as sudden falls or backward propulsion, eye or head deviation, and dystonic limb posturing followed by chorea and dyskinetic movements. Some patients may also develop epileptic seizures or only have seizures without a movement disorder.