Human Recombinant PIP4K2A, Active protein, GST Tag (V2LY-0526-LY6193)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Has both ATP- and GTP-dependent kinase activities (PubMed:26774281).
May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (PubMed:18364242).
May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity).
Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (PubMed:29353240).
In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity).
Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:31091439).
May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity).
Negatively regulates insulin signaling through a catalytic-independent mechanism (PubMed:31091439).
PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439).
Autophagosome-lysosome fusionISS:UniProtKB
Megakaryocyte developmentIEA:Ensembl
Negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of insulin receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of autophagosome assemblyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of autophagyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Vesicle-mediated cholesterol transportManual Assertion Based On ExperimentIMP:UniProtKB
Nucleus
Lysosome
Cytoplasm
Photoreceptor inner segment
Cell projection, cilium, photoreceptor outer segment
May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity).
Localization to the nucleus is modulated by the interaction with PIP4K2B
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
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Rabbit Anti-PIP4K2A Recombinant Antibody (D83C1) (CAT#: CBMAB-P1874-YC)
Mouse Anti-PIP4K2A Recombinant Antibody (1B2) (CAT#: CBMAB-P1871-YC)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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