Human Recombinant PRDX1 protein, His Tag (V2LY-0526-LY6112)

Name: Human Recombinant PRDX1 protein, His Tag
SKU: V2LY-0526-LY6112
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant PRDX1 protein, His Tag consist of Amino Acid: 1-199 and predicts a molecular mass of 22.9 kDa.

Molecule Mass

22.9 kDa

Sequence

Amino Acid: 1-199

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

peroxiredoxin 1

Alternative Names

PAG; PAGA; PAGB; PRX1; PRXI; MSP23; NKEFA; TDPX2; NKEF-A

Function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2 (PubMed:9497357).
Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).

Biological Process

Cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Cell redox homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Erythrocyte homeostasisIEA:Ensembl
Hydrogen peroxide catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Leukocyte activationManual Assertion Based On ExperimentIBA:GO_Central
Natural killer cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Natural killer cell mediated cytotoxicityIEA:Ensembl
Regulation of NIK/NF-kappaB signalingIEA:Ensembl
Regulation of stress-activated MAPK cascadeIEA:Ensembl
Removal of superoxide radicalsManual Assertion Based On ExperimentIBA:GO_Central
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB
Skeletal system developmentManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

PTM

Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.
The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant PRDX1 protein, His Tag (CAT#: V2LY-0526-LY8768)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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