Human Recombinant PTH protein, hFc Tag (V2LY-0526-LY5967)

PTH

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.

Activation of phospholipase C activityManual Assertion Based On ExperimentIMP:CAFA
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Bone mineralizationIEA:Ensembl
Bone resorption1 PublicationNAS:UniProtKB
cAMP metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell signalingManual Assertion Based On ExperimentIBA:GO_Central
Cellular calcium ion homeostasisIEA:Ensembl
Cellular macromolecule biosynthetic processManual Assertion Based On ExperimentIDA:MGI
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Homeostasis of number of cells within a tissueIEA:Ensembl
Hormone-mediated apoptotic signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Magnesium ion homeostasisIEA:Ensembl
Negative regulation of apoptotic process in bone marrow cellIEA:Ensembl
Negative regulation of bone mineralization involved in bone maturationIEA:Ensembl
Negative regulation of chondrocyte differentiationIEA:Ensembl
Negative regulation of gene expressionManual Assertion Based On ExperimentIDA:GO_Central
Phosphate ion homeostasisIEA:Ensembl
Positive regulation of bone mineralizationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell proliferation in bone marrowIEA:Ensembl
Positive regulation of glucose importManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of glycogen biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of inositol phosphate biosynthetic processManual Assertion Based On ExperimentIMP:CAFA
Positive regulation of osteoclast proliferationIEA:Ensembl
Positive regulation of signal transductionIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Regulation of gene expressionManual Assertion Based On ExperimentIDA:MGI
Response to cadmium ionIEA:Ensembl
Response to ethanolIEA:Ensembl
Response to fibroblast growth factorIEA:Ensembl
Response to lead ionIEA:Ensembl
Response to parathyroid hormoneIEA:Ensembl
Response to vitamin DIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Rho protein signal transductionIEA:Ensembl
Sskeletal system developmentManual Assertion Based On ExperimentTAS:ProtInc
Transcription by RNA polymerase IIIEA:Ensembl

Secreted

Hypoparathyroidism, familial isolated, 1 (FIH1):
A form of hypoparathyroidism, a disorder characterized by hypocalcemia and hyperphosphatemia due to a deficiency of parathyroid hormone. Clinical features include seizures, tetany and cramps. FIH1 inheritance can be autosomal dominant or recessive.