Human Recombinant RAB11B protein, His Tag (V2LY-0526-LY6431)

Name: Human Recombinant RAB11B protein, His Tag
SKU: V2LY-0526-LY6431
Rating: 5 (1 reviews)

See all RAB11B antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant RAB11B protein, His Tag consist of Amino Acid: 2-215 and predicts a molecular mass of 26.3 kDa.

Molecule Mass

26.3 kDa

Sequence

Amino Acid: 2-215

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

RAB11B,member RAS oncogene family

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.

Biological Process

Biological Process amyloid-beta clearance by transcytosisManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process cellular response to acidic pHManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process constitutive secretory pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endocytic recyclingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process establishment of protein localization to membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process insulin secretion involved in cellular response to glucose stimulusISS:UniProtKB
Biological Process melanosome transportISS:UniProtKB
Biological Process receptor recyclingISS:UniProtKB
Biological Process regulated exocytosisISS:UniProtKB
Biological Process regulation of anion transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of endocytic recyclingISS:UniProtKB
Biological Process regulation of protein localization to cell surfaceManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process transferrin transportISS:UniProtKB
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Recycling endosome membrane
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Cytoplasmic vesicle, phagosome membrane
Recruited to phagosomes containing S.aureus.

Involvement in disease

Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter (NDAGSCW):
An autosomal dominant neurodevelopmental disorder apparent in infancy and characterized by severe intellectual disability with absent speech, epilepsy, and hypotonia. Additionally, visual problems, musculoskeletal abnormalities, and microcephaly can be present. Brain imaging shows decreased cortical white matter, often with decreased cerebellar white matter, thin corpus callosum, and thin brainstem.

PTM

Citrullinated by PADI4.
(Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant RAB11B protein, His Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rat Anti-RAB11B Recombinant Antibody (10K335) (CAT#: CBMAB-R0688-CN)

Rat Anti-RAB11B Recombinant Antibody (KT80) (CAT#: CBMAB-R0693-CN)

Rat Anti-RAB11B Recombinant Antibody (KT81) (CAT#: CBMAB-R0694-CN)

Mouse Anti-RAB11B Recombinant Antibody (2F1) (CAT#: CBMAB-R0690-CN)

Rat Anti-RAB11B Recombinant Antibody (10K336) (CAT#: CBMAB-R0689-CN)

Mouse Anti-RAB11B Recombinant Antibody (6C5) (CAT#: CBMAB-BR423LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry