Human Recombinant SBDS protein, His Tag (V2LY-0526-LY6675)

Name: Human Recombinant SBDS protein, His Tag
SKU: V2LY-0526-LY6675
Rating: 5 (1 reviews)

See all SBDS antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant SBDS protein, His Tag consist of Amino Acid: 1-250 and predicts a molecular mass of 31 kDa.

Molecule Mass

31 kDa

Sequence

Amino Acid: 1-250

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

SBDS, Ribosome Maturation Factor

Function

Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

Biological Process

Biological Process bone marrow developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process bone mineralizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process hematopoietic progenitor cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process inner cell mass cell proliferationIEA:Ensembl
Biological Process leukocyte chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mature ribosome assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mitotic spindle organizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process rRNA processingManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Nucleus, nucleolus
Nucleus, nucleoplasm
Cytoplasm, cytoskeleton, spindle
Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484 and PubMed:17475909).
Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (PubMed:19759903).

Involvement in disease

Shwachman-Diamond syndrome 1 (SDS1):
A form of Shwachman-Diamond syndrome, a disorder characterized by hematopoietic abnormalities, exocrine pancreatic dysfunction, and skeletal dysplasia. Intermittent or chronic neutropenia is the most common hematological manifestation, followed by anemia and thrombocytopenia. Some patients progress to bone marrow failure, myelodysplastic syndrome and malignant transformation, with acute myelogenous leukemia being the most common. Exocrine pancreatic dysfunction is generally the first presenting symptom in infancy. Short stature and metaphyseal dysplasia are the most frequent skeletal manifestations. SDS1 inheritance is autosomal recessive.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant SBDS protein, His Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant SBDS protein, His Tag (CAT#: V2LY-0526-LY8867)

Related Products

Mouse Recombinant SBDS protein, His Tag (CAT#: V2LY-0526-LY8867)

Mouse Anti-SBDS Recombinant Antibody (CBXS-2648) (CAT#: CBMAB-S5401-CQ)

Rabbit Anti-SBDS Recombinant Antibody (CBXS-1582) (CAT#: CBMAB-S4431-CQ)

Mouse Anti-SBDS Recombinant Antibody (CBXS-6107) (CAT#: CBMAB-S2942-CQ)

Rabbit Anti-SBDS Recombinant Antibody (CBXS-1583) (CAT#: CBMAB-S4432-CQ)

Mouse Anti-SBDS Recombinant Antibody (CBXS-4083) (CAT#: CBMAB-S0207-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry