Human Recombinant SIK3, Active protein, GST Tag (V2LY-0526-LY6814)

Name: Human Recombinant SIK3, Active protein, GST Tag
SKU: V2LY-0526-LY6814
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant SIK3, Active protein, GST Tag consist of Amino Acid: 1-307 and predicts a molecular mass of 62 kDa.

Molecule Mass

62 kDa

Sequence

Amino Acid: 1-307

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

SIK family kinase 3

Function

Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230).
Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).

Biological Process

Biological Process intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process microtubule cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of TORC2 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Locates to punctate structures within the cytoplasm on binding to YWHAZ.

Involvement in disease

Spondyloepimetaphyseal dysplasia, Krakow type (SEMDK):
An autosomal recessive skeletal disorder characterized by severe spondyloepimetaphyseal dysplasia, rhizomelia, mesomelia with significant anterior bowing of all limbs, severe immunodeficiency, and developmental delay.

PTM

Phosphorylated at Thr-221 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (PubMed:14976552).
Phosphorylation at Thr-221 is inhibited in response to PTHLH/PTHrP (PubMed:30232230).
Phosphorylated at Thr-469 and Ser-551 in response to cAMP signaling (Probable).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-SIK3 Recombinant Antibody (C-2) (CAT#: CBMAB-1927-YC)

Isotype control

For research use only. Not intended for any clinical use.

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