Human Recombinant SLAMF6 protein (V2LY-0526-LY6845)

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Datasheet
SDS
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Basic Information

Expressed Host
HEK293 Cells
Protein Species
Human
Protein Construction
This product is Human Recombinant SLAMF6 protein consist of Amino Acid: 1-226 and predicts a molecular mass of 23.9 kDa.
Molecule Mass
23.9 kDa
Sequence
Amino Acid: 1-226
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile PBS
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
SLAM Family Member 6
Function
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955).
Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955).
In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity).
Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727, PubMed:16920955).
Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874).
In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4+ T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity).
Biological Process
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of interleukin-17 productionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process T cell activationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process T-helper 17 cell lineage commitmentManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 22-226
Helical: 227-247
Cytoplasmic: 248-331
PTM
Phosphorylation in NK cells upon engagment by SLAMF6-expressing target cells is leading to receptor activation.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant SLAMF6 protein, hFc Tag (CAT#: V2LY-0526-LY6846)

Human Recombinant SLAMF6 protein, His Tag (CAT#: V2LY-0526-LY6847)

Mouse Recombinant SLAMF6 protein, His Tag (CAT#: V2LY-0526-LY8915)

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Mouse Anti-SLAMF6 Recombinant Antibody (NT-7) (CAT#: CBMAB-N4263-WJ)

Mouse Anti-SLAMF6 Recombinant Antibody (13G3-19D) (CAT#: CBMAB-N0602-WJ)

Human Recombinant SLAMF6 protein, hFc Tag (CAT#: V2LY-0526-LY6846)

Human Anti-SLAMF6 Recombinant Antibody (CBXC-0816) (CAT#: CBMAB-C1930-CQ)

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Mouse Anti-SLAMF6 Recombinant Antibody (CBT3063) (CAT#: V2LY-0625-LY1027)

Rabbit Anti-SLAMF6 Recombinant Antibody (CBXS-1649) (CAT#: CBMAB-S4498-CQ)

Isotype control

For research use only. Not intended for any clinical use.

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