Human Recombinant SLC27A4 protein, His Tag (V2LY-0526-LY6857)

solute carrier family 27 (fatty acid transporter), member 4

Mediates the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across cell membranes (PubMed:10518211, PubMed:12556534, PubMed:20448275, PubMed:21395585, PubMed:22022213).
Appears to be the principal fatty acid transporter in small intestinal enterocytes (PubMed:20448275).
Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:22022213, PubMed:24269233).
Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis (By similarity).
Probably involved in fatty acid transport across the blood barrier (PubMed:21395585).
Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity).

Biological Process activation of GTPase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process establishment of localization in cellIEA:Ensembl
Biological Process fatty acid metabolic processManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process fatty acid transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process glucose import in response to insulin stimulusISS:ARUK-UCL
Biological Process lipid transport across blood-brain barrierManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process long-chain fatty acid import into cellManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process long-chain fatty acid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process long-chain fatty acid transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process medium-chain fatty acid transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activityIEA:Ensembl
Biological Process negative regulation of insulin receptor signaling pathwayManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process response to nutrientManual Assertion Based On ExperimentIBA:GO_Central
Biological Process skin developmentIEA:Ensembl
Biological Process transport across blood-brain barrier2 PublicationsNAS:ARUK-UCL
Biological Process very long-chain fatty acid catabolic processManual Assertion Based On ExperimentIBA:GO_Central

Endoplasmic reticulum membrane

Ichthyosis prematurity syndrome (IPS):
A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations.