Human Recombinant STAMBP, Active protein, His Tag (V2LY-0526-LY2103)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:15314065).
Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF (PubMed:10383417).
Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (PubMed:11483516).
Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes (PubMed:15314065, PubMed:17261583).
Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (PubMed:15314065, PubMed:17261583).
Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (PubMed:23542699).
Biological Process mitotic cytokinesisManual Assertion Based On ExperimentIMP:MGI
Biological Process negative regulation of hippocampal neuron apoptotic processIEA:Ensembl
Biological Process negative regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of Ras protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein deubiquitinationManual Assertion Based On ExperimentIMP:MGI
Biological Process protein K63-linked deubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentTAS:ProtInc
Membrane
Cytoplasm
Early endosome
A congenital disorder characterized by severe progressive microcephaly, early-onset refractory epilepsy, profound developmental delay, and multiple small capillary malformations spread diffusely on the body. Additional more variable features include dysmorphic facial features, distal limb abnormalities, and mild heart defects.
Ubiquitinated by SMURF2 in the presence of RNF11.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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