Human Recombinant THBD protein, His Tag (V2LY-0526-LY7195)

Name: Human Recombinant THBD protein, His Tag
SKU: V2LY-0526-LY7195
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant THBD protein, His Tag consist of Amino Acid: 1-515 and predicts a molecular mass of 53.54 kDa.

Molecule Mass

53.54 kDa

Verified

HPLC

Sequence

Amino Acid: 1-515

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

THBD Gene(Protein Coding) Thrombomodulin

Function

Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

Biological Process

Biological Process blood coagulationSource:ProtInc1 Publication
Biological Process blood coagulation, common pathwaySource:ComplexPortal1 Publication
Biological Process female pregnancySource:Ensembl
Biological Process negative regulation of blood coagulationSource:BHF-UCL1 Publication
Biological Process negative regulation of fibrinolysisSource:BHF-UCL1 Publication
Biological Process negative regulation of platelet activationSource:BHF-UCL1 Publication
Biological Process proteolysisSource:ComplexPortal1 Publication
Biological Process response to cAMPSource:Ensembl
Biological Process response to lipopolysaccharideSource:Ensembl
Biological Process response to X-raySource:Ensembl
Biological Process zymogen activationSource:ComplexPortal1 Publication

Cellular Location

Membrane

Involvement in disease

Thrombophilia due to thrombomodulin defect (THPH12):
A hemostatic disorder characterized by a tendency to thrombosis.
Hemolytic uremic syndrome atypical 6 (AHUS6):
An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.

Topology

Extracellular: 19-515
Helical: 516-539
Cytoplasmic: 540-575

PTM

N-glycosylated.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Recombinant THBD protein, His Tag (CAT#: V2LY-0526-LY9602)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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