Human Recombinant TTR protein, His Tag-1 (V2LY-0526-LY7362)

Name: Human Recombinant TTR protein, His Tag-1
SKU: V2LY-0526-LY7362
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant TTR protein, His Tag consist of Amino Acid: 1-147 and predicts a molecular mass of 15.2 kDa.

Molecule Mass

15.2 kDa

Verified

HPLC

Sequence

Amino Acid: 1-147

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥97% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC. ≥90% as determined by SEC-MALS(Routinely tested).

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

TTR Gene(Protein Coding) Transthyretin

Alternative Names

ATTR, HsT2651, PALB, Prealbumin, TBPA, transthyretin, TTR

Function

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Biological Process

Biological Process purine nucleobase metabolic process Source:GO_Central1 Publication
Biological Process retinol metabolic process Source:InterPro
Biological Process thyroid hormone transport Source:InterPro

Cellular Location

Secreted
Cytoplasm

Involvement in disease

Amyloidosis, transthyretin-related (AMYL-TTR):
A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.
Hyperthyroxinemia, dystransthyretinemic (DTTRH):
A condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.
Carpal tunnel syndrome 1 (CTS1):
A condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.

PTM

Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant TTR protein, His Tag (CAT#: V2LY-0526-LY7361)

Mouse Recombinant TTR protein, His Tag (CAT#: V2LY-0526-LY9015)

Human TTR ELISA Kit (CAT#: V2LY-0626-LY1455)

Pig TTR ELISA Kit (CAT#: V2LY-0626-LY702)

Mouse Ttr ELISA Kit (CAT#: V2LY-0626-LY708)

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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