Human Recombinant TYRP1 protein, His Tag (V2LY-0526-LY7470)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu2+ ions, but not in the presence of Zn2+ (PubMed:28661582).
May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458).
Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).
Biological Process melanin biosynthetic process Source:Reactome
Biological Process melanocyte differentiation Source:GO_Central1 Publication
Biological Process melanosome organization Source:GO_Central1 Publication
Biological Process positive regulation of melanin biosynthetic process Source:CACAO1 Publication
Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.
An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair.
Helical: 478-501
Cytoplasmic: 502-537
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Human Recombinant TYRP1 protein, His Tag-1 (CAT#: V2LY-0526-LY7471)
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