TYRP1

Tyrp1 catalyzes the oxidation of 5, 6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5, 6-quinone-2-carboxylic acid. may regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.
Full Name
Tyrosinase-Related Protein 1
Function
Plays a role in melanin biosynthesis (PubMed:22556244, PubMed:16704458, PubMed:23504663).
Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu2+ ions, but not in the presence of Zn2+ (PubMed:28661582).
May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458).
Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).
Biological Process
Biological Process acetoacetic acid metabolic process Source:Ensembl
Biological Process melanin biosynthetic process Source:Reactome
Biological Process melanocyte differentiation Source:GO_Central1 Publication
Biological Process melanosome organization Source:GO_Central1 Publication
Biological Process positive regulation of melanin biosynthetic process Source:CACAO1 Publication
Cellular Location
Melanosome membrane
Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.
Involvement in disease
Albinism, oculocutaneous, 3 (OCA3):
An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair.
Topology
Lumenal: 25-477
Helical: 478-501
Cytoplasmic: 502-537
PTM
Glycosylated.
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Anti-TYRP1 antibodies

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Mouse Anti-Tyrp1 Recombinant Antibody (CBYJT-5570) (CBMAB-T5203-YJ)

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Target: Tyrp1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-5570
Application*: WB, IP, IF, E
Datasheet SDS

Rat Anti-TYRP1 Recombinant Antibody (PS/2) (CBMAB-1115-LY)

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Target: TYRP1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: PS/2
Application*: N
Functional Assay
Datasheet SDS

Mouse Anti-Tyrp1 Recombinant Antibody (CBYJT-5569) (CBMAB-T5202-YJ)

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Target: Tyrp1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-5569
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-TYRP1 Recombinant Antibody (CBYJT-5568) (CBMAB-T5201-YJ)

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Target: TYRP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: CBYJT-5568
Application*: P, IF, IC
Datasheet SDS

Mouse Anti-TYRP1 Recombinant Antibody (TYRP1/807) (CBMAB-T5200-YJ)

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Target: TYRP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: TYRP1/807
Application*: F, IC, IF, P, MC
Datasheet SDS

Rabbit Anti-TYRP1 Recombinant Antibody (CBYJT-5567) (CBMAB-T5199-YJ)

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Target: TYRP1
Host: Rabbit
Antibody Isotype: IgG, κ
Specificity: Human, Mouse
Clone: CBYJT-5567
Application*: F, IC, IF, P, MC
Datasheet SDS

Mouse Anti-TYRP1 Recombinant Antibody (CBYJT-5566) (CBMAB-T5198-YJ)

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Target: TYRP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYJT-5566
Application*: WB, C, IF, IC, F
Datasheet SDS

Mouse Anti-TYRP1 Recombinant Antibody (TA99) (CBMAB-T5197-YJ)

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Target: TYRP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: TA99
Application*: WB, F, E, IC, IF, IP, C, MC
Datasheet SDS

Mouse Anti-TYRP1 Recombinant Antibody (CBYJT-5565) (CBMAB-T5196-YJ)

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Target: TYRP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: CBYJT-5565
Application*: P, IF, IC, F
Datasheet SDS

Mouse Anti-TYRP1 Recombinant Antibody (SPM456) (CBMAB-T5195-YJ)

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Target: TYRP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: SPM456
Application*: WB, F, E, IC, IF, IP, C, MC
Datasheet SDS

Mouse Anti-TYRP1 Recombinant Antibody (CBYJT-5562) (CBMAB-T5192-YJ)

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Target: TYRP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5562
Application*: IH, WB
Datasheet SDS

Mouse Anti-TYRP1 Recombinant Antibody (CBYJT-5561) (CBMAB-T5191-YJ)

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Target: TYRP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5561
Application*: WB, IH
Datasheet SDS

Mouse Anti-TYRP1 Recombinant Antibody (CBYJT-5559) (CBMAB-T5189-YJ)

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Target: TYRP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5559
Application*: IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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