Human Recombinant UBE2A, Active protein, His Tag (V2LY-0526-LY6443)

Name: Human Recombinant UBE2A, Active protein, His Tag
SKU: V2LY-0526-LY6443
Rating: 5 (1 reviews)

See all UBE2A antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant UBE2A, Active protein, His Tag consist of Amino Acid: Full Length and predicts a molecular mass of 17 kDa.

Molecule Mass

17 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

UBE2A

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.

Biological Process

Biological Process chromatin organization Source:UniProtKB-KW
Biological Process DNA repair Source:UniProtKB1 Publication
Biological Process histone H2A ubiquitination Source:UniProtKB1 Publication
Biological Process histone ubiquitination Source:GO_Central1 Publication
Biological Process positive regulation of cell population proliferation Source:UniProtKB1 Publication
Biological Process postreplication repair Source:UniProtKB1 Publication
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Biological Process protein autoubiquitination Source:UniProtKB1 Publication
Biological Process protein K11-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process response to UV Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication

Cellular Location

chromatin
cytosol
HULC complex
nucleoplasm

Involvement in disease

Intellectual developmental disorder, X-linked, syndromic, Nascimento-type (MRXSN):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXSN features include dysmorphic facies, hirsutism, skin and nails abnormalities, obesity, speech anomalies and seizures.

PTM

Phosphorylation at Ser-120 by CDK9 increases activity towards histone H2B.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant UBE2A, Active protein, His Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant UBE2A protein, His Tag (CAT#: V2LY-0526-LY6444)

Related Products

Mouse Anti-UBE2A Antibody (18D8) (CAT#: CBMAB-1719CQ)

Mouse Anti-UBE2A Antibody (9E7) (CAT#: CBMAB-1724CQ)

Human Recombinant UBE2A protein, His Tag (CAT#: V2LY-0526-LY6444)

Mouse Anti-UBE2A Antibody (5F5) (CAT#: CBMAB-1723CQ)

Rabbit Anti-UBE2A Recombinant Antibody (CBFYU-065) (CAT#: CBMAB-U0065-FY)

Mouse Anti-UBE2A Recombinant Antibody (2782C5) (CAT#: CBMAB-U0063-FY)

Mouse Anti-UBE2A Antibody (1E8) (CAT#: CBMAB-1721CQ)

Mouse Anti-UBE2A Antibody (1E7) (CAT#: CBMAB-1720CQ)

Rabbit Anti-UBE2A Recombinant Antibody (3D7-E2) (CAT#: CBMAB-U0064-FY)

Rabbit Anti-UBE2A Recombinant Antibody (CBFYU-066) (CAT#: CBMAB-U0066-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry