Human Recombinant UNC5C protein, hFc Tag (V2LY-0526-LY7547)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity).
NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977).
Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity).
Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity).
Also involved in corticospinal tract axon guidance independently of DCC (By similarity).
Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977).
It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process axon guidance Source:GO_Central1 Publication
Biological Process brain development Source:ProtInc1 Publication
Biological Process chemorepulsion of axon Source:UniProtKB
Biological Process dorsal root ganglion development Source:UniProtKB1 Publication
Biological Process ectopic germ cell programmed cell death Source:Ensembl
Biological Process positive regulation of apoptotic process Source:Ensembl
Biological Process positive regulation of developmental process Source:Ensembl
Biological Process positive regulation of reproductive process Source:Ensembl
Biological Process regulation of neuron migration Source:Ensembl
Cell surface
Synapse, synaptosome
Cell projection, axon
Cell projection, dendrite
Cell projection, growth cone
Cell projection, lamellipodium
Cell projection, filopodium
Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituents of these plaques are neurotoxic amyloid-beta protein 40 and amyloid-beta protein 42, that are produced by the proteolysis of the transmembrane APP protein. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products, such as C31, are also implicated in neuronal death.
Helical: 381-401
Cytoplasmic: 402-931
Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Human Recombinant UNC5C protein, ECD, His Tag (CAT#: V2LY-0526-LY7546)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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