Human Recombinant VWF protein, His Tag (V2LY-0526-LY7644)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Biological Process cell adhesion Source:UniProtKB1 Publication
Biological Process cell-substrate adhesion Source:UniProtKB1 Publication
Biological Process hemostasis Source:UniProtKB1 Publication
Biological Process platelet activation Source:UniProtKB1 Publication
Biological Process positive regulation of intracellular signal transduction Source:ARUK-UCL1 Publication
Biological Process response to wounding Source:UniProtKB1 Publication
Secreted, extracellular space, extracellular matrix
Localized to storage granules.
A common hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 1 is characterized by partial quantitative deficiency of circulating von Willebrand factor, that is otherwise structurally and functionally normal. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma.
von Willebrand disease 2 (VWD2):
A hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in altered platelet aggregation. Von Willebrand disease type 2 is characterized by qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and 2M are defective in their platelet-dependent function, whereas the mutant protein in type 2N is defective in its ability to bind factor VIII. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma.
von Willebrand disease 3 (VWD3):
A severe hemorrhagic disorder due to a total or near total absence of von Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII. Bleeding usually starts in infancy and can include epistaxis, recurrent mucocutaneous bleeding, excessive bleeding after minor trauma, and hemarthroses.
N- and O-glycosylated.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Human Recombinant VWF protein, A1 Domain, His Tag (CAT#: V2LY-0526-LY7641)
Human Recombinant VWF protein, Biotin Conjugated, His & AVI Tag-1 (CAT#: V2LY-0526-LY7643)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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