Human SESN1 ELISA Kit (V2LY-0626-LY3144)
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Basic Information
- Pre-coated ELISA Plate: 12 wells * 8 detachable strips
- Standard solution: 0.5ml x1
- Standard diluent: 3ml x1
- Streptavidin-HRP: 6ml x1
- Stop solution: 6ml x1
- Substrate solution A: 6ml x1
- Substrate solution B: 6ml x1
- Wash buffer concentrate (25x): 20ml x1
- Biotinylated antibody: 1ml x1
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity).
May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085).
Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity).
Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503).
However, this could not be confirmed (By similarity).
Biological Process cellular response to amino acid starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to glucose starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to leucineManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to leucine starvationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of macroautophagyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process reactive oxygen species metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of response to reactive oxygen speciesIEA:InterPro
Cytoplasm
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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