Human SLBP ELISA Kit (V2LY-0626-LY4687)
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Basic Information
- Pre-coated ELISA plate: 12 wells * 8 detachable strips
- Standard solution: 0.5ml x1
- Standard diluent: 3ml x1
- Streptavidin-HRP: 6ml x1
- Stop solution: 6ml x1
- Substrate solution A: 6ml x1
- Substrate solution B: 6ml x1
- Wash buffer concentrate (25x): 20ml x1
- Biotinylated antibody: 1ml x1
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) (PubMed:8957003, PubMed:9049306, PubMed:12588979, PubMed:19155325).
Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (PubMed:8957003, PubMed:9049306, PubMed:12588979, PubMed:19155325).
Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (PubMed:8957003, PubMed:9049306, PubMed:12588979, PubMed:19155325).
Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity).
Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity).
Biological Process mRNA 3'-end processing by stem-loop binding and cleavageISS:UniProtKB
Biological Process mRNA transportManual Assertion Based On ExperimentIDA:UniProtKB
Nucleus
Polyribosome-associated (PubMed:12588979).
Localizes predominantly in the nucleus at the G1/G2 phases and the beginning of S phase (PubMed:12588979).
Through the S phase, partially redistributes to the cytoplasm (PubMed:12588979).
Binding to histone mRNA is necessary for cytoplasmic localization (PubMed:12588979).
Shuttles between the nucleus and the cytoplasm (PubMed:15829567).
Imported in the nucleus by the Importin alpha/Importin beta receptor (PubMed:15829567).
Ubiquitinated by the CRL2(FEM1A), CRL2(FEM1B) and CRL2(FEM1C) complexes, leading to its degradation.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
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Mouse Anti-SLBP Recombinant Antibody (CBXS-4443) (CAT#: CBMAB-S1685-CQ)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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