Human SPINK5 ELISA Kit (V2LY-0626-LY5218)

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Tested Data
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Basic Information

Sensitivity
0.0096 ng/mL
Detection Range
0.02-7 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
120.7 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Serine Peptidase Inhibitor, Kazal Type 5
Function
Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin.
Biological Process
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process central nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process epidermal cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process epithelial cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process extracellular matrix organizationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process hair cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process negative regulation of angiogenesisManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process negative regulation of antibacterial peptide productionIEA:Ensembl
Biological Process negative regulation of immune responseManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process negative regulation of serine-type endopeptidase activityIEA:Ensembl
Biological Process negative regulation of serine-type peptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell adhesionIEA:Ensembl
Biological Process regulation of T cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process regulation of timing of anagenManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Secreted
Involvement in disease
Netherton syndrome (NETH):
An autosomal recessive congenital ichthyosis associated with hair shaft abnormalities and anomalies of the immune system. Typical features are ichthyosis linearis circumflexa, ichthyosiform erythroderma, trichorrhexis invaginata (bamboo hair), atopic dermatitis, and hayfever. High postnatal mortality is due to failure to thrive, infections and hypernatremic dehydration.
PTM
Proteolytically processed by furin in individual domains (D1, D5, D6, D8 through D11, and D9 through D15) exhibiting various inhibitory potentials for multiple proteases.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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