Human TMPRSS2 ELISA Kit (V2LY-0626-LY3286)

transmembrane protease, serine 2

Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198).
Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198).
In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity).
(Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436, PubMed:34159616, PubMed:33051876).
Upon SARS-CoV-2 infection, increases syncytia formation by accelerating the fusion process (PubMed:34159616, PubMed:33051876).
Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.

Biological Process positive regulation of viral entry into host cellSource:UniProtKB3 Publications
Biological Process protein autoprocessingSource:UniProtKB1 Publication
Biological Process proteolysisSource:UniProtKB2 Publications

Cell membrane
Transmembrane protease serine
Secreted
Activated by cleavage and secreted.

Cytoplasmic: 1-84
Helical: 85-105
Extracellular: 106-492

Proteolytically processed; by an autocatalytic mechanism.