Human UBE2V1 ELISA Kit (V2LY-0626-LY5410)

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Tested Data
Datasheet
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Basic Information

Sensitivity
0.034 ng/mL
Detection Range
0.07-15 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
16.5 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Ubiquitin Conjugating Enzyme E2 V1
Function
Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (PubMed:31006531).
UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway.
Biological Process
Biological Process cell differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:HGNC-UCL1 Publication
Biological Process positive regulation of intracellular signal transduction Source:ComplexPortal1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:HGNC-UCL1 Publication
Biological Process positive regulation of protein K63-linked ubiquitination Source:ComplexPortal1 Publication
Biological Process postreplication repair Source:GO_Central1 Publication
Biological Process protein K63-linked ubiquitination Source:UniProtKB3 Publications
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process regulation of DNA repair Source:ProtInc1 Publication
Biological Process regulation of DNA-templated transcription Source:UniProtKB1 Publication
Cellular Location
Nucleus
Excluded from the nucleolus.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-UBE2V1 Recombinant Antibody (G-6) (CAT#: CBMAB-C4405-CN)

Isotype control

For research use only. Not intended for any clinical use.

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