Human ZEB2 ELISA Kit (V2LY-0626-LY3857)

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Tested Data
Request for COA
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Basic Information

Sensitivity
0.024 ng/mL
Detection Range
0.05-30 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
136.4 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
ZEB2
Function
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212).
Represses transcription of E-cadherin (PubMed:16061479).
Represses expression of MEOX2 (PubMed:20516212).
Biological Process
Biological Process anatomical structure development Source:GO_Central1 Publication
Biological Process developmental pigmentation Source:BHF-UCLBy Similarity
Biological Process melanocyte migration Source:BHF-UCLBy Similarity
Biological Process negative regulation of transcription by RNA polymerase II Source:BHF-UCL2 Publications
Biological Process nervous system development Source:UniProtKB1 Publication
Biological Process positive regulation of canonical Wnt signaling pathway Source:DIBU1 Publication
Biological Process positive regulation of melanin biosynthetic process Source:BHF-UCL1 Publication
Biological Process positive regulation of melanocyte differentiation Source:BHF-UCLBy Similarity
Biological Process positive regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process positive regulation of transforming growth factor beta receptor signaling pathway Source:DIBU1 Publication
Biological Process regulation of melanosome organization Source:BHF-UCLBy Similarity
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Cellular Location
Nucleus
Chromosome
Involvement in disease
Mowat-Wilson syndrome (MOWS):
A complex developmental disorder characterized by intellectual disability, delayed motor development, epilepsy, microcephaly and a wide spectrum of clinically heterogeneous features suggestive of neurocristopathies at the cephalic, cardiac, and vagal levels. Affected patients show an easily recognizable facial appearance with deep set eyes and hypertelorism, medially divergent, broad eyebrows, prominent columella, pointed chin and uplifted, notched ear lobes. Some patients manifest Hirschsprung disease.
PTM
Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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