Human ZP3 ELISA Kit (V2LY-0626-LY5444)

zona pellucida sperm-binding protein 3

Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

Biological Process binding of sperm to zona pellucida Source:UniProtKB2 Publications
Biological Process blastocyst formation Source:UniProtKB
Biological Process egg coat formation Source:UniProtKB
Biological Process humoral immune response mediated by circulating immunoglobulin Source:UniProtKB
Biological Process negative regulation of binding of sperm to zona pellucida Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB
Biological Process oocyte development Source:UniProtKB
Biological Process positive regulation of acrosomal vesicle exocytosis Source:UniProtKB1 Publication
Biological Process positive regulation of acrosome reaction Source:UniProtKB3 Publications
Biological Process positive regulation of antral ovarian follicle growth Source:UniProtKB
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB
Biological Process positive regulation of humoral immune response Source:UniProtKB1 Publication
Biological Process positive regulation of inflammatory response Source:UniProtKB
Biological Process positive regulation of interleukin-4 production Source:UniProtKB
Biological Process positive regulation of leukocyte migration Source:UniProtKB
Biological Process positive regulation of ovarian follicle development Source:UniProtKB
Biological Process positive regulation of T cell proliferation Source:UniProtKB
Biological Process positive regulation of type II interferon production Source:UniProtKB
Biological Process positive regulation of type IV hypersensitivity Source:UniProtKB

Processed zona pellucida sperm-binding protein 3
Zona pellucida
Cell membrane

Oocyte maturation defect 3 (OOMD3):
An autosomal dominant infertility disorder characterized by abnormal oocytes that lack the zona pellucida, and oocytes degeneration.

Extracellular: 23-387
Helical: 388-408
Cytoplasmic: 409-424

Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
N-glycosylated.
O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy.