IL6 Matched Antibody Pair (637) (APMAB-637LY)

Name: IL6 Matched Antibody Pair (637)
SKU: APMAB-637LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-IL6 monoclonal, IgG2a antibody, 100 ug

Detection Antibody

Anti-IL6 Biotinylated mouse monoclonal, IgG2b antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Alternative Names

Interleukin 6

Entrez Gene ID

3569

UniProt ID

P05231

More Infomation

McAndrews, K. M., Chen, Y., Darpolor, J. K., Zheng, X., Yang, S., Carstens, J. L., ... & Kalluri, R. (2022). Identification of functional heterogeneity of carcinoma-associated fibroblasts with distinct IL6-mediated therapy resistance in pancreatic cancer. Cancer discovery, 12(6), 1580-1597.

Martínez-Pérez, C., Kay, C., Meehan, J., Gray, M., Dixon, J. M., & Turnbull, A. K. (2021). The IL6-like cytokine family: Role and biomarker potential in breast cancer. Journal of personalized medicine, 11(11), 1073.

Jing, B., Wang, T., Sun, B., Xu, J., Xu, D., Liao, Y., ... & Deng, J. (2020). IL6/STAT3 signaling orchestrates premetastatic niche formation and immunosuppressive traits in lung. Cancer research, 80(4), 784-797.

Siersbæk, R., Scabia, V., Nagarajan, S., Chernukhin, I., Papachristou, E. K., Broome, R., ... & Carroll, J. S. (2020). IL6/STAT3 signaling hijacks estrogen receptor α enhancers to drive breast cancer metastasis. Cancer Cell, 38(3), 412-423.

Rossotti, R., Travi, G., Ughi, N., Corradin, M., Baiguera, C., Fumagalli, R., ... & Niguarda COVID-19 Working Group. (2020). Safety and efficacy of anti-il6-receptor tocilizumab use in severe and critical patients affected by coronavirus disease 2019: A comparative analysis. Journal of Infection, 81(4), e11-e17.

Rosa, M., Chignon, A., Li, Z., Boulanger, M. C., Arsenault, B. J., Bossé, Y., ... & Mathieu, P. (2019). A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity. NPJ genomic medicine, 4(1), 23.

Qiao, Y., Zhang, C., Li, A., Wang, D., Luo, Z., Ping, Y., ... & Zhang, Y. (2018). IL6 derived from cancer-associated fibroblasts promotes chemoresistance via CXCR7 in esophageal squamous cell carcinoma. Oncogene, 37(7), 873-883.

Cheng, Y., Li, H., Deng, Y., Tai, Y., Zeng, K., Zhang, Y., ... & Yang, Y. (2018). Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma. Cell death & disease, 9(4), 422.

Kato, T., Noma, K., Ohara, T., Kashima, H., Katsura, Y., Sato, H., ... & Fujiwara, T. (2018). Cancer-associated fibroblasts affect intratumoral CD8+ and FoxP3+ T cells via IL6 in the tumor microenvironment. Clinical Cancer Research, 24(19), 4820-4833.

Tsukamoto, H., Fujieda, K., Miyashita, A., Fukushima, S., Ikeda, T., Kubo, Y., ... & Oshiumi, H. (2018). Combined blockade of IL6 and PD-1/PD-L1 signaling abrogates mutual regulation of their immunosuppressive effects in the tumor microenvironment. Cancer research, 78(17), 5011-5022.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus, Rhesus Recombinant IL6 protein (CAT#: V2LY-0526-LY1724)

Human Recombinant IL6 protein (CAT#: V2LY-0526-LY4942)

Human Recombinant IL6 protein-1 (CAT#: V2LY-0526-LY4943)

Human Recombinant IL6 protein, Biotin Conjugated, (CAT#: V2LY-0526-LY4944)

Mouse Recombinant IL6 protein (CAT#: V2LY-0526-LY8551)

Rat Recombinant IL6 protein (CAT#: V2LY-0526-LY9481)

Sus scrofa (Pig) Recombinant IL6 protein (CAT#: V2LY-0526-LY9836)

Human Recombinant IL6, GMP grade protein (CAT#: V2LY-0526-LY4945)

Cattle IL6 ELISA Kit (CAT#: V2LY-0626-LY121)

Rabbit IL6 ELISA Kit (CAT#: V2LY-0626-LY127)

Antibody Pairs

IL6 Matched Antibody Pair (636) (CAT#: APMAB-636LY)

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Rat Recombinant IL6 protein (CAT#: V2LY-0526-LY9481)

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Mouse Recombinant IL6 protein (CAT#: V2LY-0526-LY8551)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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