IL6R Matched Antibody Pair (638) (APMAB-638LY)

Name: IL6R Matched Antibody Pair (638)
SKU: APMAB-638LY
Rating: 5 (1 reviews)

See all IL6R antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-IL6R monoclonal antibody, 100 ug

Detection Antibody

Anti-IL6R Biotinylated mouse monoclonal, IgG1 antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]

Alternative Names

Interleukin 6 Receptor

Entrez Gene ID

3570

UniProt ID

P08887

More Infomation

Hamilton, F. W., Thomas, M., Arnold, D., Palmer, T., Moran, E., Mentzer, A. J., ... & Timpson, N. J. (2023). Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study. PLoS Medicine, 20(1), e1004174.

Maiti, S., Banerjee, A., Nazmeen, A., Kanwar, M., & Das, S. (2022). Active-site molecular docking of nigellidine with nucleocapsid–NSP2–MPro of COVID-19 and to human IL1R–IL6R and strong antioxidant role of Nigella sativa in experimental rats. Journal of Drug Targeting, 30(5), 511-521.

Teoh, P. J., Chung, T. H., Chng, P. Y., Toh, S. H., & Chng, W. J. (2020). IL6R-STAT3-ADAR1 (P150) interplay promotes oncogenicity in multiple myeloma with 1q21 amplification. haematologica, 105(5), 1391.

Strafella, C., Caputo, V., Termine, A., Barati, S., Caltagirone, C., Giardina, E., & Cascella, R. (2020). Investigation of genetic variations of IL6 and IL6R as potential prognostic and pharmacogenetics biomarkers: implications for COVID-19 and neuroinflammatory disorders. Life, 10(12), 351.

Nouri, B., Nair, N., & Barton, A. (2020). Predicting treatment response to IL6R blockers in rheumatoid arthritis. Rheumatology, 59(12), 3603-3610.

Buonaguro, F. M., Puzanov, I., & Ascierto, P. A. (2020). Anti-IL6R role in treatment of COVID-19-related ARDS. Journal of translational medicine, 18, 1-2.

Jia, C., Wang, G., Wang, T., Fu, B., Zhang, Y., Huang, L., ... & Liu, W. (2020). Cancer-associated Fibroblasts induce epithelial-mesenchymal transition via the Transglutaminase 2-dependent IL-6/IL6R/STAT3 axis in Hepatocellular Carcinoma. International journal of biological sciences, 16(14), 2542.

Deng, N., Li, L., Gao, J., Zhou, J., Wang, Y., Wang, C., & Liu, Y. (2018). Hsa_circ_0009910 promotes carcinogenesis by promoting the expression of miR-449a target IL6R in osteosarcoma. Biochemical and biophysical research communications, 495(1), 189-196.

Tamura, Y., Phan, C., Tu, L., Le Hiress, M., Thuillet, R., Jutant, E. M., ... & Guignabert, C. (2018). Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension. The Journal of clinical investigation, 128(5), 1956-1970.

Zhang, B., Yu, L., Han, N., Hu, Z., Wang, S., Ding, L., & Jiang, J. (2018). LINC01116 targets miR-520a-3p and affects IL6R to promote the proliferation and migration of osteosarcoma cells through the Jak-stat signaling pathway. Biomedicine & Pharmacotherapy, 107, 270-282.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used IL6R Matched Antibody Pair (638)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IL6R protein, His Tag (CAT#: V2LY-0526-LY4946)

Human Recombinant IL6R protein, ECD, Biotin Conjugated, AVI & Fc Tag (CAT#: V2LY-0526-LY4947)

Human Recombinant IL6R protein, ECD, hFc Tag (CAT#: V2LY-0526-LY4948)

Human Recombinant IL6R protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY4949)

Human Recombinant IL6R protein, ECD, His Tag (CAT#: V2LY-0526-LY4950)

Human Recombinant IL6R protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY4951)

Rat Recombinant IL6R protein, ECD, hFc Tag (CAT#: V2LY-0526-LY9482)

Rat Recombinant IL6R protein, ECD, His Tag (CAT#: V2LY-0526-LY9483)

Canine Recombinant IL6R protein, ECD, His Tag (CAT#: V2LY-0526-LY1289)

Mouse Recombinant IL6R protein, His Tag (CAT#: V2LY-0526-LY8552)

Related Products

Rat Anti-IL6R Recombinant Antibody (15A7) (CAT#: CBMAB-1042-LY)

Mouse Anti-IL6R Recombinant Antibody (CBYY-I0235) (CAT#: CBMAB-I0612-YY)

Rat Anti-IL6R Recombinant Antibody (CBYY-I0236) (CAT#: CBMAB-I0616-YY)

Mouse Anti-IL6R Recombinant Antibody (CBYY-I1900) (CAT#: CBMAB-I3070-YY)

Mouse Anti-IL6R Recombinant Antibody (CBYY-I1208) (CAT#: CBMAB-I2377-YY)

Mouse Anti-IL6R Recombinant Antibody (17506) (CAT#: CBMAB-I0614-YY)

Mouse Anti-IL6R Recombinant Antibody (CBYY-I1394) (CAT#: CBMAB-I2564-YY)

Human Recombinant IL6R protein, ECD, hFc Tag (CAT#: V2LY-0526-LY4948)

Mouse Anti-IL6R Recombinant Antibody (UV4) (CAT#: CBMAB-C11738-LY)

Mouse Anti-IL6R Recombinant Antibody (CBYY-I0797) (CAT#: CBMAB-I1774-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry