JAK/STAT Pathway Phosphorylation Array
EGFR (P-Ser1070), JAK1 (P-Tyr1022), JAK2 (P-Tyr1007/1008), SHP-1 (P-Ser591), SHP2 (P-Tyr542), Src (P-Tyr419), STAT1 (P-Ser727), STAT2 (P-Tyr689), STAT3 (P-Tyr705), STAT5 (P-Tyr694), STAT6 (P-Tyr641), TYK2 (P-Tyr1054)
Cell culture supernatants, Cell lysates, Plasma, Serum and Tissue lysates
Multiplexed Protein Detection
Block the array membrane surface
Incubate with Sample
Incubate with Detection Antibody Cocktail
Incubate with HRP Conjugated Anti-Rabbit IgG Antibodies
Incubate with Detection Buffers
Image with chemiluminescent imaging system
Antibody Array Membrane
Store at -20°C for 6 months. Once thawed, please keep reagents under suitable conditions respectively for no more than 3 months. Do not use past expiration date.
The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. The pathway communicates information from chemical signals outside of a cell to the cell nucleus, resulting in the activation of genes through a process called transcription. There are three key parts of JAK-STAT signalling: Janus kinases (JAKs), signal transducer and activator of transcription proteins (STATs), and receptors (which bind the chemical signals). Disrupted JAK-STAT signalling may lead to a variety of diseases, such as skin conditions, cancers, and disorders affecting the immune system.