KIT Matched Antibody Pair (672) (APMAB-672LY)

Name: KIT Matched Antibody Pair (672)
SKU: APMAB-672LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-KIT monoclonal antibody, 100 ug

Detection Antibody

Anti-KIT Biotinylated mouse monoclonal, IgG1 antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Alternative Names

KIT Proto-Oncogene Receptor Tyrosine Kinase; V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog; Tyrosine-Protein Kinase Kit; Piebald Trait Protein; Proto-Oncogene C-Kit; EC 2.7.10.1; P145 C-Kit; SCFR; PBT; V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene-Like Protein;

Entrez Gene ID

3815

UniProt ID

P10721

More Infomation

Sheikh, E., Tran, T., Vranic, S., Levy, A., & Bonfil, R. D. (2022). Role and significance of c-KIT receptor tyrosine kinase in cancer: A review. Bosnian Journal of Basic Medical Sciences, 22(5), 683.

Naumann, N., Lübke, J., Shomali, W., Reiter, L., Horny, H. P., Jawhar, M., ... & Schwaab, J. (2021). Clinical and histopathological features of myeloid neoplasms with concurrent Janus kinase 2 (JAK2) V617F and KIT proto‐oncogene, receptor tyrosine kinase (KIT) D816V mutations. British journal of haematology, 194(2), 344-354.

K. Bhanumathy, K., Balagopal, A., Vizeacoumar, F. S., Vizeacoumar, F. J., Freywald, A., & Giambra, V. (2021). Protein tyrosine kinases: their roles and their targeting in leukemia. Cancers, 13(2), 184.

Esteban-Villarrubia, J., Soto-Castillo, J. J., Pozas, J., San Román-Gil, M., Orejana-Martín, I., Torres-Jiménez, J., ... & Molina-Cerrillo, J. (2020). Tyrosine kinase receptors in oncology. International journal of molecular sciences, 21(22), 8529.

Nordgaard, C., Doll, S., Matos, A. L. D. S. A., Høeberg, M., Kazi, J. U., Friis, S., ... & Manuel Afonso Moreira, J. (2019). Metallopeptidase inhibitor 1 (TIMP‐1) promotes receptor tyrosine kinase c‐Kit signaling in colorectal cancer. Molecular Oncology, 13(12), 2646-2662.

Roskoski Jr, R. (2018). The role of small molecule Kit protein-tyrosine kinase inhibitors in the treatment of neoplastic disorders. Pharmacological research, 133, 35-52.

Wang, H., Boussouar, A., Mazelin, L., Tauszig-Delamasure, S., Sun, Y., Goldschneider, D., ... & Mehlen, P. (2018). The proto-oncogene c-Kit inhibits tumor growth by behaving as a dependence receptor. Molecular cell, 72(3), 413-425.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant KIT (d557-558), Active protein, GST Tag (CAT#: V2LY-0526-LY3154)

Human Recombinant KIT (d557-558, V654A), Active protein, GST Tag (CAT#: V2LY-0526-LY3155)

Human Recombinant KIT (d557-558, V654A, Y823D), Active protein, GST Tag (CAT#: V2LY-0526-LY3156)

Human Recombinant KIT (d557-558, Y823D), Active protein, GST Tag (CAT#: V2LY-0526-LY3157)

Human Recombinant KIT (d560-576), Active protein, GST Tag (CAT#: V2LY-0526-LY3158)

Human Recombinant KIT (d560-576, V654A), Active protein, GST Tag (CAT#: V2LY-0526-LY3159)

Human Recombinant KIT (d560-576, Y823D), Active protein, GST Tag (CAT#: V2LY-0526-LY3160)

Human Recombinant KIT (D816E), Active protein, GST Tag (CAT#: V2LY-0526-LY3161)

Human Recombinant KIT (D816F), Active protein, GST Tag (CAT#: V2LY-0526-LY3162)

Human Recombinant KIT (D816H), Active protein, GST Tag (CAT#: V2LY-0526-LY3163)

Antibody Pairs

KIT Matched Antibody Pair (668) (CAT#: APMAB-668LY)

KIT Matched Antibody Pair (669) (CAT#: APMAB-669LY)

KIT Matched Antibody Pair (670) (CAT#: APMAB-670LY)

KIT Matched Antibody Pair (671) (CAT#: APMAB-671LY)

Related Products

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Mouse Anti-KIT Recombinant Antibody (C117/370 + KIT/982 + KIT/983) (CAT#: CBMAB-C5253WJ)

Rabbit Anti-KIT Recombinant Antibody (YR145) (CAT#: CBMAB-0426CQ)

Mouse Anti-KIT Recombinant Antibody (CBYY-C2791) (CAT#: CBMAB-C4232-YY)

Human Recombinant KIT (d560-576), Active protein, GST Tag (CAT#: V2LY-0526-LY3158)

Mouse Anti-KIT Recombinant Antibody (CBXC-0663) (CAT#: CBMAB-C4283-CQ)

Human Recombinant KIT (V559A), Active protein, GST Tag (CAT#: V2LY-0526-LY3182)

Mouse Anti-KIT Recombinant Antibody (CBWJC-3957) (CAT#: CBMAB-C5260WJ)

Human Recombinant KIT (d557-558, V654A), Active protein, GST Tag (CAT#: V2LY-0526-LY3155)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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